Scratching the itch: is scabies a truly neglected disease?

Chosidow, Olivier; Fuller, L.C.

doi:10.1016/s1473-3099(17)30469-3

Cited by 20 publications

(12 citation statements)

References 8 publications

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“…Scabies is a parasitic skin disease caused by Sarcoptes scabiei and is characterized by severe itch . The mechanisms of itch in scabies are unclear, but likely involve the immune response .…”

Section: Basophils and Pruritic Skin Diseasesmentioning

confidence: 99%

Possible roles of basophils in chronic itch

Hashimoto

Rosen

Sanders

et al. 2018

Experimental Dermatology

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Basophils are blood granulocytes and normally constitute <1% of blood peripheral leucocytes. Basophils share some morphological and functional similarities with mast cells, and basophils were once regarded as redundant and negligible circulating mast cells. However, recent studies reveal the indispensable roles of basophils in various diseases, including allergic and pruritic diseases. Basophils may be involved in itch through the mediation of a Th2 immune response, interaction with other cells in the skin and secretion of a wide variety of itch-related mediators, for example histamine, cytokines and chemokines (IL-4, IL-13, IL-31 and TSLP), proteases (cathepsin S), prostaglandins (PGE2 and PGD2), substance P and platelet-activating factor. Not only pruritic skin diseases (eg, atopic dermatitis, irritant contact dermatitis, chronic urticaria, prurigo, papulo-erythroderma of Ofuji, eosinophilic pustular folliculitis, scabies, tick bites and bullous pemphigoid) but also pruritic systemic diseases (eg, primary sclerosing cholangitis and polycythemia vera) may be affected by basophils.

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Section: Basophils and Pruritic Skin Diseasesmentioning

confidence: 99%

Possible roles of basophils in chronic itch

Hashimoto

Rosen

Sanders

et al. 2018

Experimental Dermatology

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“…Cases of scabies reach around 100–130 million yearly, and the condition is distributed worldwide [ 1 ]. It represents a significant global burden [ 3 , 7 ], involving school absenteeism, psycho-social impacts, and impetigo and its complications, in particular in low-resource countries. This explains why scabies has recently been added to the WHO’s list of neglected tropical diseases ( http://www.who.int/neglected_diseases/diseases/en ).…”

mentioning

confidence: 99%

High-dose ivermectin in malaria and other parasitic diseases: a new step in the development of a neglected drug

2018

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“…Another possibility to consider is the presence of other bacterial infection as a complication of the most frequent scabies. The ineffectiveness of anti-scabies drugs might due to the presence of secondary infection of S. aureus bacteria, which required treatment should be for the bacterial infections first before the use of anti-scabies [9]. Some other methods are needed that might improve the adherence of santri in using anti-scabies drugs.…”

Section: Discussionmentioning

confidence: 99%

A Journey to a Better Community Service in Religious Boarding School Pesantren

Triyani¹,

Yuniarti²,

Tejasari³

et al. 2019

Proceedings of the Social and Humaniora Research Symposium (SoRes 2018)

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Global scabies prevalence at religious boarding school (Pesantren) is still a big problem especially in developing countries. This article describes one of the processes of the problem-solving method through community service with the objectives that members of the community behave in a healthy way towards a scabies-free Pesantren. The target audience is a pesantren consisting of students and teaching staff in urban areas. Previous results showed that there was an increase scabies incident from the first scabies screening although immediately after the first screening the students treated with anti-scabies drugs. The level of students' knowledge about scabies was the majority in the good category. This study concludes that efforts to improve students to behave in a clean and healthy living will be a long journey, requiring ongoing assistance and cooperation of various parties.

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Scratching the itch: is scabies a truly neglected disease?

Cited by 20 publications

References 8 publications

Possible roles of basophils in chronic itch

Possible roles of basophils in chronic itch

High-dose ivermectin in malaria and other parasitic diseases: a new step in the development of a neglected drug

A Journey to a Better Community Service in Religious Boarding School Pesantren

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