Scratch Patch Testing to Dermabond in a Patient With Suspected Allergic Contact Dermatitis

Patel, Kajal; Nixon, Rosemary

doi:10.1097/der.0000000000000941

Cited by 2 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous adult studies have demonstrated the efficacy of both patch and scratch tests to confirm allergy to 2-octylcyanocrylate or Dermabond in the event of a suspected reaction to the adhesive 12,22,25 . Scratch patch testing has demonstrated to be the most accurate when testing for Dermabond allergy in comparison to standard patch testing but has not been reported in children 24 . Finally, we studied only 3/16 surgeons in our practice, but they represented almost 50% of our Dermabond cases in 2019.…”

Section: Discussionmentioning

confidence: 97%

“…Ricciardo et al 13 reported a case series of 6 patients—all with histories of prior exposures to cyanoacrylates as well as 4 with prior surgical exposure to Dermabond—who experienced ACD due to Dermabond application following an orthopedic procedure. Patel & Nixon 24 reported the case of an 18-year-old patient who did not develop a skin reaction at her first exposure to Dermabond during an orthopedic procedure but developed a scratch patch test confirmed ACD, due to Dermabond following a second surgical exposure to the adhesive. The etiology of skin sensitivity following Dermabond application is likely multifactorial, and the ultimate cause is elusive.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Incidence of Skin Sensitivity Following Dermabond Application in Pediatric Orthopedic Surgery

Koritz,

Canizares,

Cook

et al. 2023

Journal of Pediatric Orthopaedics

View full text Add to dashboard Cite

Background: Dermabond (Dermabond; Ethicon, Sommerville, NJ), is a skin adhesive commonly utilized in pediatric orthopedic surgery for postoperative wound care. Few studies have examined outcomes of Dermabond exposure in children. The purpose of this study is to estimate the incidence of skin reactions following Dermabond exposure in pediatric orthopedic surgery and investigate potential risk factors associated with Dermabond sensitivity. Methods: This was a retrospective study of a level-one pediatric trauma center. All orthopaedic surgeries in 2019 were screened for Dermabond application. Three surgeons with the highest rates of Dermabond application defined our cohort. Out of 2990 surgeries in 2019, the 3 surgeons performed 234 surgeries with Dermabond. Postoperative reactions and repeat Dermabond exposures were collected for these 234 patients. Subjects with known allergies to Dermabond were excluded. Reactions were defined. as discoloration, irritation, and wound dehiscence. Significant differences between patients with repeat Dermabond exposures and those without were determined using χ2 analysis. Associations between patient characteristics and sensitivity were determined using logistic regression analysis. P values less than 0.05 were considered significant. Results: In all, 234 patients were included for analysis. The mean age at surgery was 12.5 years (SD 6.1), and 39% (92/234) of the cohort was male. Thirty-two patients (14%) experienced skin reactions during the study period (95% CI=7%–19%). Reactions most frequently included. erythema (10/32; 31%) and itchiness (10/32; 31%). Reactions were most frequently treated with oral antibiotics, Benadryl, or a dressing change. Of 144 patients with 1 Dermabond exposure, 17 (12%) experienced reactions (95% CI=7%–18%). Of 128 patients experiencing a repeat Dermabond exposure, 27 (21%) experienced reactions (95% CI=19%–34%, P=0.03). Age, surgical procedure, and surgical location were not, associated with a variable rate of sensitivity. Conclusions: Sensitivity to Dermabond after pediatric orthopedic surgery occurred at a higher rate than seen in adults, and patients with multiple Dermabond exposures experienced significantly higher sensitivity than patients with a single exposure. Increased awareness of this potential complication is needed to help inform decisions regarding Dermabond’s application in pediatric orthopedics.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Incidence of Skin Sensitivity Following Dermabond Application in Pediatric Orthopedic Surgery

Koritz,

Canizares,

Cook

et al. 2023

Journal of Pediatric Orthopaedics

View full text Add to dashboard Cite

show abstract

“…If clinical suspicion remains high, scratch patch testing may confirm contact allergy in cases of negative testing on intact skin. 49…”

Section: A B C Dmentioning

confidence: 99%

Tackling Acrylate Allergy: The Sticky Truth

Rodriguez

2023

Cutis

View full text Add to dashboard Cite

Acrylates are synthetic thermoplastic resins used in numerous industries since their discovery in the mid-19th century. Known for their versatility in formulating various consumer, health care, and industrial products, acrylates also have come under scrutiny for their potential to cause allergic contact dermatitis (ACD). Allergic contact dermatitis to acrylates previously was largely occupational in nature, but the expanded use of acrylates in products ranging from nail cosmetics to medical devices has increasingly brought this allergy to the general population. Herein, we discuss the chemistry and allergenicity of acrylates and highlight common sources of exposure, clinical presentations, pertinent considerations for patch testing, and tips for the management/prevention of acrylate ACD. We hope to emphasize the shifting trend of exposure sources from the workplace to consumers, underlining the need for increased vigilance from physicians. Collaborative efforts among health care providers and patient education about allergen avoidance strategies are essential to mitigate potential complications arising from acrylate sensitization.Cutis. 2023;112:282-286.• When patch testing for suspected acrylate allergy, 2-hydroxyethyl methacrylate (HEMA) is the most important screening allergen. Expanded testing to additional acrylates should be considered depending on the clinical scenario.

show abstract

Scratch Patch Testing to Dermabond in a Patient With Suspected Allergic Contact Dermatitis

Cited by 2 publications

References 6 publications

Incidence of Skin Sensitivity Following Dermabond Application in Pediatric Orthopedic Surgery

Incidence of Skin Sensitivity Following Dermabond Application in Pediatric Orthopedic Surgery

Tackling Acrylate Allergy: The Sticky Truth

Contact Info

Product

Resources

About