ZAP70 expression in regulatory T cells in allergic rhinitis: effect of immunotherapy

Abstract

SIT with grass pollen effectively reduces rhinitis severity and affects allergic airway inflammation reflected by reduction of ENO. Beneficial role of immunotherapy may result not only from the induction of Treg numbers but especially from cell activation and restitution of Treg intracellular signal transduction.

Decreased allergy incidence in children supplemented with E. coli O83:K24:H31 and its possible modes of action

“…In the current report, only non‐significantly increased proportion of Tregs was found in peripheral blood of allergic children. This discrepancy could be caused by sampling at different part of allergy season , different number of children inspected in the current study and the usage of other kit for Treg detection together with altered panel of antibodies because more parameters were tested in the present work. Especially utilization of distinct clones of antibody against FoxP3 could lead to the controversy on Treg proportion as every clone binds to various epitopes on FoxP3 which can be influenced by activation status of Tregs and this could further contribute to the inconsistency .…”

Allergen immunotherapy improves defective follicular regulatory T cells in patients with allergic rhinitis

“…Induction of Treg cells has been proposed as one of the mechanisms underlying the benefit of AIT, but the results were not always consistent. [24][25][26][27] It is of great interest to know how AIT might affect T FR cells. Thus we conducted a prospective study to investigate this question.…”

Histamine Type 2 Receptor Expression on Peripheral Blood Regulatory Lymphocytes in Patients with Allergic Rhinitis Treated with Specific Immunotherapy

“…Histamine, released in higher amounts during the pollen season, may act through H2R on Treg cells and encourage their suppression of inflammation; however, in symptomatic patients with AR this mechanism seems to be not effective. The total fraction of Treg cells did not change, 25 whereas the subset of Treg cells with H2Rs in the peripheral blood significantly increased, simultaneously with escalated rhinitic symptoms, inflammation within the nasal mucosa reflected by nasal eosinophilia.…”

“…The total fraction of Treg cells did not change, 25 whereas the subset of Treg cells with H2Rs in the peripheral blood significantly increased, simultaneously with escalated rhinitic symptoms, inflammation within the nasal mucosa reflected by nasal eosinophilia.…”