WDR61 ablation triggers R‐loop accumulation and suppresses breast cancer progression
Yayan Hou,
Chunyong Zhang,
Ling Liu
et al.
Abstract:Although, superkiller complex protein 8 (SKI8), previously known as WDR61 has been identified and mapped in breast tumor, little is currently known about its function. This study aims to elucidate the role of WDR61 in breast tumor development and its potential as a therapeutic target. Here, we show that tamoxifen‐induced knockout of Wdr61 reduces the risk of breast tumors, resulting in smaller tumor size and weight, and improved overall survival. Furthermore, we show that knockdown of WDR61 compromises the pro… Show more
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