TRPA1 receptor is upregulated in human oral lichen planus

Abstract

We provided evidence for the extraneuronal presence and upregulation of the proinflammatory TRPA1 receptor in buccal samples of patients with OLP. This may implicate the ion channel in the pathomechanism of OLP.

Next step: functional studies on hypertension, lichen planus, and TRPA1 connections

“…Our results based on mRNA and protein expression (Kun et al, 2016), and epidemiological correlations (Lowe et al, 1976;Ellgehausen et al, 1998;Dissemond, 2004;Scully and Carrozzo, 2008;Balakumar et al, 2015) have so far provided indirect evidence for Ang II exacerbating OLP.…”

TRPA1 may contribute to the exacerbation of oral lichen planus through Koebner phenomenon

“…Oral lichen planus often develops in the sites of mechanical trauma, for example buccal mucosa (Eisen, 2002;Gorouhi et al, 2014), suggesting a mechanical role in the pathogenesis of oral LP. Given that TRPA1 was upregulated in oral LP lesions (Kun et al, 2016) and that activated TRPA1 plays an important role in mucosal or cutaneous immune reactions (Liu et al, 2013;Oh et al, 2013), we suggest TRPA1 could be activated by mechanical stimuli and evoke oral LP.…”

“…Given that circulating angiotensin-converting enzyme (the enzyme the produces angiotensin II) was upregulated in LP patients (Alendar et al, 2005), TRPA1 would be activated and upregulated in both lesion sites and non-lesion sites. However, unfortunately, this study (Kun et al, 2016) did not examine the expression levels of TRPA1 in non-lesion sites.…”

“…TRPA1 may be activated in non-lesion sites among LP patients It has been reported that angiotensin-converting enzyme inhibitor (ACEI) could protect people from developing oral lichen planus (Clayton et al, 2010). Interestingly, Kun et al (2016) found that the expression levels of TRPA1 were significantly lower in OLP patients taking ACEI than in those not. Moreover, a recent study revealed that angiotensin II was able to activate TRPA1 (Shepherd and Mohapatra, 2016).…”

“…We would like to congratulate Kun et al (2016) for their recent publication entitled: 'TRPA1 receptor is upregulated in human oral lichen planus'. This article is very informative and enlightening, and it was a great read.…”