The influence of topical5%tranexamic acid at pH2.38with and without corundum microdermabrasion on pigmentation and skin surface lipids

Abstract

Tranexamic acid (TA) has anti-hemorrhagic effects; however, oral administration has been found to decrease hyperpigmentation. The aim of the work was to compare the effects of treatment with 5% tranexamic acid in combination with corundum microdermabrasion on skin pigmentation, redness, pH, transepidermal water loss (TEWL), sebum level and hydration of back surface and dorsal surface of the hand skin. Six treatments were performed every week on the back surface and both dorsal surfaces of the hands of 12 subjects. The entire back/both hands were treated with 5% tranexamic acid at pH 2.38; left side of the back or left hand were also subjected to corundum microdermabrasion. Skin parameters were measured using the Courage & Khazaka 580 Multi Probe Adapter. Clinical photos were taken using the Fotomedicus system. Significant differences between treatment methods were observed for melanin, erythema and pH. In addition, the two methods differed significantly with regard to the amount of sebum, TEWL and the level of moisture in the skin. Both methods gave similar acidic pH. Summing up tranexamic acid causes a significant reduction in epidermal melanogenesis, has a significant impact on the level of skin hydration, lipids of the epidermis and maintaining the proper TEWL. TA has a significant effect on reducing skin redness.

A prospective, split-Face, comparative study of combined Q-switch Nd:YAG laser and microdermabrasion versus Q-switch Nd:YAG laser alone in treatment of melasma

“…Therefore, we could not compare our results with previous studies. However, both treatment modalities were used previously and their clinical efficacy was found to be superior compared to topical agents (29)(30) This study confirmed the efficacy and safety of laser with or without microdermabrasion, but we could not find any difference between two study groups in terms of clinical response or safety profile. In fact, none of our patients experienced post inflammatory hyperpigmentation which could be due to use of lightening agents before initiation of and during the study as well as using conservative setting for laser treatment.…”

Evaluating the effect of tranexamic acid as mesotherapy on persistent post‐acne erythema: A before and after study

“…In a 2020 study by Batory et al on the effect of topical TA 5% with and without microderm abrasion on skin pigmentation and lipids showed significant reduction of melanogenesis and increase hydration of the epidermis 30 …”

“…with and without microderm abrasion on skin pigmentation and lipids showed significant reduction of melanogenesis and increase hydration of the epidermis. 30 A 2021 study by Behrangi et al, on patients with melasma identified the benefits of this substance. In this study, patients with melasma were studied by two methods, Nd-Yag Fraction 1064 + microinjection of TA and Nd-Yag Fraction 1064+ oral TA.…”