TET2 deficiency exacerbates nasal polypogenesis by inducing epithelial‐to‐mesenchymal transition

Downregulation of TET2 Contributes to Nasal Polypogenesis Through Hypoxia-Inducible Factor 1α-Mediated Epithelial-to-Mesenchymal Transition

“…We employed a C57BL/6J murine NP model induced by OVA and SEB to investigate the roles of TET2 and EMT in our study, which likely represents an eosinophilic NP model. Although a neutrophilic murine NP model might have been more appropriate, our prior research indicated that the expression of EMT showed no significant difference between eosinophilic CRSwNP and non-eosinophilic CRSwNP groups in human subjects [ 43 , 44 ]. Therefore, we chose to develop this eosinophilic NP model to mirror the characteristics of this inflammatory disease.…”

“…Second, it would be beneficial to design a series of varying concentrations of VC to determine whether the activation of TET2 by VC in nasal epithelial cells is dose-dependent and to identify the most appropriate concentration. Third, our previous studies did not find a significant difference in the expression of EMT markers and TET2 between patients with eosinophilic CRSwNP and those with non-eosinophilic CRSwNP [ 44 ]; therefore, we did not categorize the patients into these two groups. However, further research is needed to ascertain whether there is a difference in TET2 expression between patients with eosinophilic CRSwNP and those with neutrophilic CRSwNP, which would deepen our understanding of the condition.…”