T_H17 cells, interleukin‐17 and interferon‐ γ in patients and households contacts of leprosy with multibacillary and paucibacillary forms before and after the start of chemotherapy treatment

Abstract

The principal finding was that TH17 lymphocytes and interleukin-17 actively participating in the immune response of Hansen's disease as well these cells can stimulate the cellular immunity.

Circulatory level of IL-6 and INF-γ in Sudanese leprosy patients

“…Our result agrees with Nada and Saini [21,22]. Also INF-γ was higher in PB than in MB which is concordant with the results of De Almeida-Neto, Nada, Saini, and Madan [21,23,30]. The pauci bacillary (PB) types of infection are portrayed by the power of a Th1-type immune response, the nearness of all around shaped granulomas at the site of the injury because of fiery CMI, and control of mycobacterial replication.…”

Retracted: S100A9 gene silencing inhibits the release of pro‐inflammatory cytokines by blocking the IL‐17 signalling pathway in mice with acute pancreatitis

“…A recent study explored the relationship between pancreatic cancer, S100A9/A8 and transforming growth factor beta 1 (TGFβ1) concluded that the overexpression of S100A9/A8 by infiltrating inflammatory cells and the expressions is related to TGFβ1 in pancreatic ductal adenocarcinoma (PDAC) . Interleukin‐17 (IL‐17), a pro‐inflammatory cytokine mainly produced by T‐helper 17 (Th 17) cells, has been reported to play a crucial role in the development of an effective immune response . Liu et al reported that IL‐17 played a pivotal role in the pathogenesis of numerous inflammatory diseases in the central nervous system (CNS), such as multiple sclerosis and stoke, whereas Dai et al suggested that serum IL‐17 was an early prognostic biomarker of severe acute pancreatitis in patients receiving continuous blood purification .…”

“…11 Interleukin-17 (IL-17), a pro-inflammatory cytokine mainly produced by T-helper 17 (Th 17) cells, has been reported to play a crucial role in the development of an effective immune response. 12,13 Liu et al reported that IL-17 played a pivotal role in the pathogenesis of numerous inflammatory diseases in the central nervous system (CNS), such as multiple sclerosis and stoke, 14 whereas Dai et al suggested that serum IL-17 was an early prognostic biomarker of severe acute pancreatitis in patients receiving continuous blood purification. 15 However, few studies have appeared to place an emphasis on the effects of S100A9 and the release of proinflammatory cytokines through the IL-17 signalling pathway in AP.…”

The protective role of tissue-resident interleukin 17A–producing gamma delta T cells in Mycobacterium leprae infection

“…Interleukin 17A (IL-17A) is generally considered as a proinflammatory cytokine. IL-17A has been shown to play a protective role in the early stages of infection by triggering macrophages and boosting Th1 effector cells (6,7). Saini et al discovered CD4 + Th17 cells in the patients infected with Mycobacterium tuberculosis and emphasized the significance of these cells in leprosy.…”

“…Interleukin 17A (IL-17A) is generally considered as a pro-inflammatory cytokine. IL-17A has been shown to play a protective role in the early stages of infection by triggering macrophages and boosting Th1 effector cells ( 6 , 7 ). Saini et al.…”