2012
DOI: 10.1002/eji.201242624
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T cells induced by recombinant chimpanzee adenovirus alone and in prime‐boost regimens decrease chimeric EcoHIV/NDK challenge virus load

Abstract: The popularity of nonreplicating adenoviruses of chimpanzee origin (ChAdVs) as vectors for subunit vaccines is on the rise. This is mainly for their excellent safety and impressive immunogenicity observed in human studies to date. Here, we recloned the chimpanzee adenovirus sero type 68 (ChAdV-68), also designated SAdV-25 and AdC68, genome and demonstrated its straightforward genetic manipulation facilitated by the use of bacterial artificial chromosome recombineering. To generate the ChAdV68.GagB vaccine, the… Show more

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Cited by 18 publications
(16 citation statements)
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References 51 publications
(87 reference statements)
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“…Pre‐clinical studies establish that the AdC68 vector is highly immunogenic and effective at inducing cytotoxic T lymphocytes specific to HIV‐1 antigens [Pinto et al, 2004; Reyes‐Sandoval et al, 2004; de Souza et al, 2007]. An AdC68‐based HIV vaccine also induces a protective effector memory response against the challenge of chimeric ecotropic HIV and induces robust polyfunctional HIV‐1‐specific CD8 + and CD4 + T‐cell responses in mice [Roshorm et al, 2012].…”
Section: Introductionmentioning
confidence: 99%
“…Pre‐clinical studies establish that the AdC68 vector is highly immunogenic and effective at inducing cytotoxic T lymphocytes specific to HIV‐1 antigens [Pinto et al, 2004; Reyes‐Sandoval et al, 2004; de Souza et al, 2007]. An AdC68‐based HIV vaccine also induces a protective effector memory response against the challenge of chimeric ecotropic HIV and induces robust polyfunctional HIV‐1‐specific CD8 + and CD4 + T‐cell responses in mice [Roshorm et al, 2012].…”
Section: Introductionmentioning
confidence: 99%
“…ecombinant adenoviruses (Ads) are currently being explored as candidate vaccine vectors for multiple pathogens (1)(2)(3)(4)(5)(6), as a result of their safety profile, manufacturability, and ability to induce broad and strong immune responses (7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Multiple human and chimpanzee adenovirus vectors have been developed to date (8,9,(11)(12)(13).…”
mentioning
confidence: 99%
“…Results are graphed as mean ± SEM, * represents when p < 0.05. Roshorm et al, 2012;Saini et al, 2007). EcoHIV is a pseudotyped virus that can infect mouse, but not human, leukocytes and is based on HIV NL4-3 (clade B) in which the HIV gp120 envelope protein was substituted with gp80 from murine leukaemia virus (Potash et al, 2005).…”
Section: Long Term Protection Is Partially Lost With the Inclusion Ofmentioning
confidence: 99%