STA‐21 regulates Th‐17/Treg balance and synovial fibroblasts functions in rheumatoid arthritis
Talar Ahmad Merza Mohammad,
Badraldin Kareem Hamad,
Avin Mohammad Arif Maroof
et al.
Abstract:JAK/STAT signaling pathway plays a significant role in cytokines and growth factors signaling involved in the pathogenesis of rheumatoid arthritis (RA). STAT3 is a major downstream signaling mediator of important pro‐inflammatory cytokines involved in Th‐17 cell differentiation playing a significant role in regulating Th‐17/ Treg balance and the development of autoimmune diseases, especially RA. Studies also have reported the role of the STAT3 pathway in inflammatory and destructive functions of synovial fibro… Show more
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