<scp>SOX</scp>‐11 regulates <scp>LINE</scp>‐1 retrotransposon activity during neuronal differentiation

Orqueda, Andres J.; Gatti, Cintia Romina; Ogara, María Florencia; Falzone, Tomás L.

doi:10.1002/1873-3468.13260

Cited by 8 publications

(6 citation statements)

References 53 publications

(65 reference statements)

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“…Two binding sites for SRY factors have been mapped in the human L1 promoter region, and both are required for the activation of an L1 reporter system in human rhabdomyosarcoma (RD) cells (Tchénio et al 2000). SOX11 was specifically shown to transactivate a reporter gene in RD cells, which has been further supported in a recent study demonstrating the direct role of SOX11 in activating L1Hs during SH-SY5Y cells neuronal differentiation (Orqueda et al 2018). SOX2 was shown to repress L1Hs transcription in neural stem cells.…”

Section: Dynamic Evolution Of Te Regulatory Regionsmentioning

confidence: 83%

TFs for TEs: the transcription factor repertoire of mammalian transposable elements

Hermant

Torres-Padilla

2021

Genes Dev.

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Transposable elements (TEs) are genetic elements capable of changing position within the genome. Although their mobilization can constitute a threat to genome integrity, nearly half of modern mammalian genomes are composed of remnants of TE insertions. The first critical step for a successful transposition cycle is the generation of a full-length transcript. TEs have evolved cis-regulatory elements enabling them to recruit host-encoded factors driving their own, selfish transcription. TEs are generally transcriptionally silenced in somatic cells, and the mechanisms underlying their repression have been extensively studied. However, during germline formation, preimplantation development, and tumorigenesis, specific TE families are highly expressed. Understanding the molecular players at stake in these contexts is of utmost importance to establish the mechanisms regulating TEs, as well as the importance of their transcription to the biology of the host. Here, we review the transcription factors known to be involved in the sequence-specific recognition and transcriptional activation of specific TE families or subfamilies. We discuss the diversity of TE regulatory elements within mammalian genomes and highlight the importance of TE mobilization in the dispersal of transcription factor-binding sites over the course of evolution.

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Section: Dynamic Evolution Of Te Regulatory Regionsmentioning

confidence: 83%

TFs for TEs: the transcription factor repertoire of mammalian transposable elements

Hermant

Torres-Padilla

2021

Genes Dev.

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“…The L1 promoter region also contains two SRY-binding sites for the SOX transcription factor family [388], expressed in embryonic tissues, testes, and in various tissues in the adult body with the highest expression level in the brain, especially for the SOX2 factor [244]. SOX11 regulates L1 during the differentiation of neuronal tissues [388,389]. SOX2 enhances L1 expression in hippocampal neuronal stem cells in the adult brain [113,390].…”

Section: Positive Regulation Of L1mentioning

confidence: 99%

Factors Regulating the Activity of LINE1 Retrotransposons

Protasova

Andreeva

Rogaev

2021

Genes

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LINE-1 (L1) is a class of autonomous mobile genetic elements that form somatic mosaicisms in various tissues of the organism. The activity of L1 retrotransposons is strictly controlled by many factors in somatic and germ cells at all stages of ontogenesis. Alteration of L1 activity was noted in a number of diseases: in neuropsychiatric and autoimmune diseases, as well as in various forms of cancer. Altered activity of L1 retrotransposons for some pathologies is associated with epigenetic changes and defects in the genes involved in their repression. This review discusses the molecular genetic mechanisms of the retrotransposition and regulation of the activity of L1 elements. The contribution of various factors controlling the expression and distribution of L1 elements in the genome occurs at all stages of the retrotransposition. The regulation of L1 elements at the transcriptional, post-transcriptional and integration into the genome stages is described in detail. Finally, this review also focuses on the evolutionary aspects of L1 accumulation and their interplay with the host regulation system.

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“…Consistently, we showed that GATA2 was downregulated in high-risk NB. Consistently, ID1, SOX11, TFAP2B, KLF7, and GATA3 were linked to neurogenesis or NB differentiation [ 13 , 18 , 19 , 23 , 71 , 72 ], but to our knowledge, these studies did not discuss their association with survival and risk groups in NB, hence our findings are novel.…”

Section: Discussionmentioning

confidence: 57%

Deep analysis of neuroblastoma core regulatory circuitries using online databases and integrated bioinformatics shows their pan-cancer roles as prognostic predictors

et al. 2021

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Aim Neuroblastoma is a heterogeneous childhood cancer derived from the neural crest. The dual cell identities of neuroblastoma include Mesenchymal (MES) and Adrenergic (ADRN). These identities are conferred by a small set of tightly-regulated transcription factors (TFs) binding super enhancers, collectively forming core regulatory circuitries (CRCs). The purpose of this study was to gain a deep understanding of the role of MES and ADRN TFs in neuroblastoma and other cancers as potential indicators of disease prognosis, progression, and relapse. Methods To that end, we first investigated the expression and mutational profile of MES and ADRN TFs in neuroblastoma. Moreover, we established their correlation with neuroblastoma risk groups and overall survival while establishing their extended networks with long non-coding RNAs (lncRNAs). Furthermore, we analysed the pan-cancer expression and mutational profile of these TFs and their correlation with patient survival and finally their network connectivity, using a panel of bioinformatic tools including GEPIA2, human pathology atlas, TIMER2, Omicsnet, and Cytoscape. Results We show the association of multiple MES and ADRN TFs with neuroblastoma risk groups and overall survival and find significantly higher expression of various MES and ADRN TFs compared to normal tissues and their association with overall survival and disease-free survival in multiple cancers. Moreover, we report the strong correlation of the expression of these TFs with the infiltration of stromal and immune cells in the tumour microenvironment and with stemness and metastasis-related genes. Furthermore, we reveal extended pan-cancer networks comprising these TFs that influence the tumour microenvironment and metastasis and may be useful indicators of cancer prognosis and patient survival. Conclusion Our meta-analysis shows the significance of MES and ADRN TFs as indicators of patient prognosis and the putative utility of these TFs as potential novel biomarkers.

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SOX‐11 regulates LINE‐1 retrotransposon activity during neuronal differentiation

Cited by 8 publications

References 53 publications

TFs for TEs: the transcription factor repertoire of mammalian transposable elements

TFs for TEs: the transcription factor repertoire of mammalian transposable elements

Factors Regulating the Activity of LINE1 Retrotransposons

Deep analysis of neuroblastoma core regulatory circuitries using online databases and integrated bioinformatics shows their pan-cancer roles as prognostic predictors

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