Small‐RNA‐guided histone modifications and somatic genome elimination in ciliates
Thomas Balan,
Leticia Koch Lerner,
Daniel Holoch
et al.
Abstract:Transposable elements and other repeats are repressed by small‐RNA‐guided histone modifications in fungi, plants and animals. The specificity of silencing is achieved through base‐pairing of small RNAs corresponding to the these genomic loci to nascent noncoding RNAs, which allows the recruitment of histone methyltransferases that methylate histone H3 on lysine 9. Self‐reinforcing feedback loops enhance small RNA production and ensure robust and heritable repression. In the unicellular ciliate Paramecium tetra… Show more
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