<scp>Sars‐Cov</scp>‐2 in a Patient with Acute Chorea: Innocent Bystander or Unexpected Actor?

Ramusino, Matteo Cotta; Perini, Giulia; Corrao, Gabriele; Farina, Lisa Maria; Berzero, Giulia; Ceroni, Mauro; Costa, Alfredo

doi:10.1002/mdc3.13274

Cited by 9 publications

(10 citation statements)

References 10 publications

(11 reference statements)

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“…4 In addition, a 62-year-old man has been reported with acute chorea after getting a Sars-Cov-2 infection, and the authors concluded that inflammation may have played a role in the development of chorea in this patient. 5 Presentation of hemichorea in our patients suggests an inflammatory mechanism, as the first patient had inflammatory white matter changes on brain MRI, but the occurrence in the two cousins may indicate the possibility of a genetic predisposition as a factor for developing this phenomenon.…”

Section: Two Cousins With Acute Hemichorea After Bbibp-corv (Sinophar...mentioning

confidence: 65%

“…3 Not surprisingly, there has been significant public interest in MRgFUS given its less invasive approach, further fueled by increasing numbers of mainstream media articles recently. 4,5 Precisely since MRgFUS adoption in Toronto in 2013, we noted a significant increase in the number of patients referred to our movement disorders center for tremor management. Thus, we decided to focus on the referral pattern of tremor patients during the years 2014 to 2018 to have enough time to record the final decision.…”

Section: Two Cousins With Acute Hemichorea After Bbibp-corv (Sinophar...mentioning

confidence: 99%

“…In addition, a 62‐year‐old man has been reported with acute chorea after getting a Sars‐Cov‐2 infection, and the authors concluded that inflammation may have played a role in the development of chorea in this patient. 5 …”

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confidence: 99%

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Two Cousins with Acute Hemichorea after BBIBP‐CorV (Sinopharm) COVID‐19 Vaccine

Salari

Etemadifar

2022

Movement Disorders

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Section: Two Cousins With Acute Hemichorea After Bbibp-corv (Sinophar...mentioning

confidence: 65%

Section: Two Cousins With Acute Hemichorea After Bbibp-corv (Sinophar...mentioning

confidence: 99%

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Two Cousins with Acute Hemichorea after BBIBP‐CorV (Sinopharm) COVID‐19 Vaccine

Salari

Etemadifar

2022

Movement Disorders

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“…In a prospective study by Ray et al [8] on the prevalence of COVID-19 neurological manifestations among 1,334 children, two cases of acute chorea were reported. Byrnes et al [9], Hassan et al [5] and Cotta Ramusino et al [10] reported COVID-19-associated chorea in adults, most probably due to non-infectious encephalitis. Ghosh et al [11] reported a case of chorea in the course of diabetic ketoacidosis triggered by SARS-CoV-2 infection.…”

mentioning

confidence: 99%

Acute-onset chorea and confusional state in 77-year-old COVID-19 patient: a case report

Sawczyńska

Wężyk

Bosak

et al. 2022

Neurol Neurochir Pol.

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“…As far as we know, the two patient cases noted below are the first to be reported with more than a 2‐week interval between post‐COVID‐19 encephalitis and initiation of chorea. 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 …”

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confidence: 99%

Chorea as a Post‐COVID‐19 Complication

Ashrafi

Salari

Pour

2022

Movement Disord Clin Pract

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Severe acute respiratory syndrome (SARS) coronavirus (COV)-2 causes flu-like symptoms, including fever, cough, fatigue, and loss of sense of smell. Although many complications of this unprecedented virus have been specified, there is still a lack of information on neurologic post-recovery complications. Studies suggest that this rapidly spreading virus can invade the nervous system and cause neurological problems even after recovery. 1 The most common neurological complications include headache, dizziness, myalgia, anosmia, gustatory, and olfactory dysfunctions. 2 Severe disorders such as encephalopathy, encephalitis, necrotizing hemorrhagic encephalopathy, stroke, epileptic seizures, rhabdomyolysis, and Guillain-Barre syndrome have also been reported after coronavirus disease (COVID)-19 infection. 3 There are just six case reports on post-COVID-19 chorea. As far as we know, the two patient cases noted below are the first to be reported with more than a 2-week interval between post-COVID-19 encephalitis and initiation of chorea. [4][5][6][7][8][9][10][11] A 67-year-old woman was referred to the movement disorder clinic because of acute onset of generalized choreiform movements. She stated an earlier admission because of coronavirus symptoms including nausea, loss of appetite, and high blood pressure 3 months prior. Moreover, she tested positive for coronavirus reverse-transcription polymerase chain reaction (RT-PCR) by nasopharyngeal swab. Additionally, 2 weeks after the beginning of her COVID-19 infection, she developed confusion, illusion, aphasia, imbalance, and delirium. Consequently, she was diagnosed with post-COVID-encephalitis and received a tocilizumab injection. She was vaccinateded for COVID-19 (AstraZeneca) 4 months previously. Her family history and previous history of any abnormal movements in any part of her body were negative.She had normal neurological and systemic examinations. However, she was suffering from choreiform movements in her face and all four limbs, with right arm dominancy (Video 1). Brain magnetic resonance imaging (MRI) showed bilateral hyperintensity on fluid-attenuated inversion recovery and T2 imaging on basal ganglia (Fig. 1). She was treated with tetrabenazine (12.5 mg twice daily). After a few days, her symptoms recovered rapidly, and she was discharged.Another 62-year-old otherwise healthy female presented to the movement disorder clinic because she experienced sudden onset abnormal movements in her truncal and limbs. She had been admitted 15 days previously because of her COVID-19 infection and treated with a remdesivir injection. Her past medical history, drug history, and family history were unremarkable. She had no pathological findings in examinations and brain MRI. Nonetheless, she had choreiform movements on her extremities, especially on the right side (Video 2). She was treated with tetrabenazine and chorea dramatically mended.Video 1. Shows the patient with choreiform movements in face and all four limbs, more prominently in the right upper extremity.

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Sars‐Cov‐2 in a Patient with Acute Chorea: Innocent Bystander or Unexpected Actor?

Cited by 9 publications

References 10 publications

Two Cousins with Acute Hemichorea after BBIBP‐CorV (Sinopharm) COVID‐19 Vaccine

Two Cousins with Acute Hemichorea after BBIBP‐CorV (Sinopharm) COVID‐19 Vaccine

Acute-onset chorea and confusional state in 77-year-old COVID-19 patient: a case report

Chorea as a Post‐COVID‐19 Complication

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