Resina Draconis as a topical treatment for pressure ulcers: A systematic review and meta‐analysis

Abstract

In recent years, a number of studies have reported on Resina Draconis (RD) as a topical treatment for pressure ulcers. To evaluate these studies, we performed a systematic review and meta-analysis aimed to examine the efficacy of RD for pressure ulcers. We searched eight electronic databases to identify randomized controlled trials in which RD treatment was compared with other topical treatment of pressure ulcers from 1980 to 2014. Selection of studies, study appraisal, data extraction and analysis were undertaken using standard methods. Fourteen randomized controlled trials were included involving 618 patients. The results of the meta-analysis showed that, RD treatment was significantly associated with a higher healing rate for pressure ulcers (risk ratio 2.07, 95% confidence intervals 1.73-2.48, p < 0.001). The results of descriptive analysis showed that, compared with the control group, RD treatment shortened healing time. As for safety, adverse reactions had not been reported. These results suggest that RD can improve the healing rate for pressure ulcers and shorten the healing time, compared with other topical treatments. However, due to limited quality and quantity of the included studies, this conclusion needs to be proved by more high quality studies.

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

“…Resina Draconis (RD), which is a resin obtained from D. cochinchinensis , is a popular traditional Chinese medicine widely used for the management of various conditions including cerebral arterial thrombosis, ischemic heart disease, and trauma and allergic dermatitis . Several therapeutic effects of RD has been described including its antitumor, antidiabetes, analgesic, anti‐inflammatory, and immunomodulatory activities.…”

miR‑339‑5p negatively regulates loureirin A‑induced hair follicle stem cell differentiation by targeting DLX5

“…Small molecules can be used to promote HFSC activation, which will be useful for regenerative medicine ( 10 ). Resina draconis , a traditional Chinese herbal medicine, has a long history of clinical efficacy against wounds, ulcers and other hard-to-heal injuries ( 11 ). Our previous study indicated that loureirin A, the main active flavonoid ingredient of Resina draconis , can promote HFSC differentiation by activating the protein Wnt-9b (Wnt)/β-catenin signaling pathway and inducing HFSC-seeded tissue-engineered skin to repair skin wounds ( 12 ).…”

Effect of Loureirin B on Crohn’s disease rat model induced by TNBS via IL-6/STAT3/NF-κB signaling pathway

“…Over the years, Chinese medicine has accumulated a wealth of experience in the treatment of CD, a large number of literature reports and modern research have confirmed that Chinese medicine in the treatment of CD has a significant effect [47][48][49]. LB as a Chinese herb has been commonly used for the treatment of coronary heart disease, angina, and acute myocardial infarction, and the ethyl acetate of LB can promote inflammatory response induced with LPS through inhibiting ROS production in vascular smooth muscle cells and macrophages [19][20][21][22]. However, the role of LB on CD and the underlying mechanisms remain unknown.…”

“…RD, obtained from Dracaena cochinchinensis (Lour.) S. C. Chen (Liliaceae), is a Chinese herb with the positive activities of promoting blood circulation for removing blood stasis, regenerating tissue to heal wound, relieving pain and eliminating swelling, which has been commonly used for the treatment of coronary heart disease, angina, and acute myocardial infarction [19,20]. Additionally, the ethyl acetate of RD can promote inflammatory response induced by LPS through inhibiting ROS production in vascular smooth muscle cells and macrophages [21].…”