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            aman Spectroscopy in Medicine

Krafft, Christoph; Rösch, Petra; Popp, Jürgen

doi:10.1002/3527600434.eap680

Cited by 2 publications

(2 citation statements)

References 136 publications

(110 reference statements)

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“…Magnetic resonance tomography (MRT), computed tomography (CT), and positron emission tomography (PET) are imaging techniques that are used to determine the location and size of a brain tumor. CT, MRT, and PET scans require contrast agents to produce clear images of the tumor [ 132 ]. The transcapillary transport of water-soluble compounds can be measured by PET methods in vivo.…”

Section: Ai In Brain Tumor Imagingmentioning

confidence: 99%

Artificial Intelligence and Precision Medicine: A New Frontier for the Treatment of Brain Tumors

Philip

Samuel

Bhatia

et al. 2022

Life

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Brain tumors are a widespread and serious neurological phenomenon that can be life- threatening. The computing field has allowed for the development of artificial intelligence (AI), which can mimic the neural network of the human brain. One use of this technology has been to help researchers capture hidden, high-dimensional images of brain tumors. These images can provide new insights into the nature of brain tumors and help to improve treatment options. AI and precision medicine (PM) are converging to revolutionize healthcare. AI has the potential to improve cancer imaging interpretation in several ways, including more accurate tumor genotyping, more precise delineation of tumor volume, and better prediction of clinical outcomes. AI-assisted brain surgery can be an effective and safe option for treating brain tumors. This review discusses various AI and PM techniques that can be used in brain tumor treatment. These new techniques for the treatment of brain tumors, i.e., genomic profiling, microRNA panels, quantitative imaging, and radiomics, hold great promise for the future. However, there are challenges that must be overcome for these technologies to reach their full potential and improve healthcare.

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Section: Ai In Brain Tumor Imagingmentioning

confidence: 99%

Artificial Intelligence and Precision Medicine: A New Frontier for the Treatment of Brain Tumors

Philip

Samuel

Bhatia

et al. 2022

Life

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“…High‐resolution spectroscopic analysis and ultrafast, short‐pulse interrogation are the two main modalities of optical technologies based on nonlinear Raman scattering . While high‐resolution Raman spectroscopy requires narrowband probes, capable of resolving individual molecular or atomic features in often crowded Raman spectra of complex chemical systems, broadband, short‐pulse drivers offer a vast arsenal of tools for time‐resolved studies of ultrafast dynamics in physical, chemical, and biological systems and open a whole new world of chemically specific, high‐speed nonlinear microscopy . The requirements on laser fields needed to implement these modalities are seemingly incompatible.…”

Section: Introduction and Wolfgang Kiefer's Legacymentioning

confidence: 99%

A compact laser platform for nonlinear Raman microspectroscopy: multimodality through broad chirp tunability

Lanin

Stepanov

Tikhonov

et al. 2016

J Raman Spectroscopy

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We demonstrate a compact laser platform that integrates stimulated and coherent Raman microscopy with high-resolution nonlinear Raman spectroscopy. Ultrashort laser pulses with a carefully managed, broadly tunable chirp are shown to enable a comfortable switching between the high-contrast microscopy and high-resolution spectroscopy modalities in both stimulated and coherent versions of nonlinear Raman scattering. Sub-10-cm À1 spectral resolution in stimulated Raman spectroscopy is demonstrated through a careful compensation of nonlinear phase distortions of ultrashort laser pulses. This offers a powerful tool for a reliable identification of molecular vibrations with close frequencies, enhancing the chemical selectivity of spectroscopic analysis of complex multicomponent systems. Introduction and Wolfgang Kiefer's legacyHigh-resolution spectroscopic analysis and ultrafast, short-pulse interrogation are the two main modalities of optical technologies based on nonlinear Raman scattering. [1,2] While high-resolution Raman spectroscopy [3,4] requires narrowband probes, capable of resolving individual molecular or atomic features in often crowded Raman spectra of complex chemical systems, broadband, shortpulse drivers offer a vast arsenal of tools [5,6] for time-resolved studies of ultrafast dynamics in physical, chemical, and biological systems [1,2,7] and open a whole new world of chemically specific, high-speed nonlinear microscopy. [8][9][10] The requirements on laser fields needed to implement these modalities are seemingly incompatible.Wolfgang Kiefer, one of the pioneers of the field of Raman spectroscopy, whose work had a profound impact on the field and who prominently contributed to the development of high-spectralresolution Raman methods, [11,12] was also among the first visionary scientists who recognized the tremendous potential of emerging short-pulse laser sources for Raman technologies. [13][14][15] This vision has in many ways shaped the future of the field. Within the past two decades, nonlinear Raman processes driven by ultrashort pulses have played a central role in ultrafast science, providing methods that help to probe [16,17] and control [18][19][20][21] ultrafast processes on the picosecond, femtosecond, and attosecond time scale, [22] as well as open new horizons in standoff detection [23,24] and ultrashort waveform synthesis. [25,26] With a powerful impetus gained from the invention of nonlinear Raman microscopy, [8,27] short-pulse Raman techniques find growing applications in bioimaging, enabling a chemically selective, high-frame-rate detection of intracellular dynamics, [28] diagnostics of lipid membranes, [29] and neurophysiological studies. [30][31][32][33][34] Ultrashort laser pulses inevitably impose limitations on the spectral resolution in nonlinear-optical microspectroscopy, making it difficult to resolve closely lying and overlapping lines in Raman spectra and to extract the informative signal in the microscopy of multicomponent biological systems. However, the coherence of laser p...

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R aman Spectroscopy in Medicine

Cited by 2 publications

References 136 publications

Artificial Intelligence and Precision Medicine: A New Frontier for the Treatment of Brain Tumors

Artificial Intelligence and Precision Medicine: A New Frontier for the Treatment of Brain Tumors

A compact laser platform for nonlinear Raman microspectroscopy: multimodality through broad chirp tunability

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