Pullulan‐Collagen hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings

Abstract

Biological scaffolds such as hydrogels provide an ideal, physio-mimetic of native extracellular matrix (ECM) that can improve wound healing outcomes after cutaneous injury. While most studies have focused on the benefits of hydrogels in accelerating wound healing, there are minimal data directly comparing different hydrogel material compositions. In this study, we utilized a splinted excisional wound model that recapitulates human-like wound healing in mice and treated wounds with three different collagen hydrogel dressings. We assessed the feasibility of applying each dressing and performed histologic and histopathologic analysis on the explanted scar tissues to assess variations in collagen architecture and alignment, as well as the tissue response. Our data indicate that the material properties of hydrogel dressings can significantly influence healing time, cellular response, and resulting architecture of healed scars. Specifically, our pullulan-collagen hydrogel dressing accelerated wound closure and promoted healed tissue with less dense, more randomly aligned, and shorter collagen fibres. Further understanding of how hydrogel properties affect the healing and resulting scar architecture of wounds may lead to novel insights and further optimization of the material properties of wound dressings.

Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting

“…To inhibit mechanotransduction in porcine wounds treated with STSG, we delivered FAKI (VS-6062) using a biodegradable, biocompatible, and soft pullulan-based hydrogel optimized for sustained drug release during wound healing (Fig. 3, A and B) (23,65). FAK is a critical transducer of integrin-matrix forces to downstream intracellular pathways (22).…”

Integrated Optical Coherence Tomography and Deep Learning for Evaluating of the Injectable Hydrogel on Skin Wound Healing

“…In conclusion, most current studies consider hydrogels to be ideal candidates for synthetic wound dressings because of their 3D structure and high water content similar to skin, which ensures a moist environment for wounds [96,97]. A wide variety of polymers have been used alone or in blends to create hydrogels designed for biomedical applications, with a focus on wound healing and less scarring [98][99][100][101]. In addition, most of the current research shows that non-invasive optical technology DRS and OCT may be useful for research related to abnormal wound healing.…”

Emerging Effects of Resveratrol on Wound Healing: A Comprehensive Review

“…Due to the low bioavailability of RSV for oral ingestion and the water-insoluble nature of RSV, various types of wound dressings have been developed for topical treatment [ 11 , 12 ]. Increasingly, studies have designed new drug delivery systems for topical application of RSV or have modified the structural characteristics of RSV to improve its bioavailability during systemic ingestion and eventually develop this potential molecule as a first-line treatment against various diseases [ 13 ]. However, before the clinical potential of RSV can be fully accepted, appropriate application protocols must be designed for both systemic and topical subcutaneous.…”