ProBAN: Neural network algorithm for predicting binding affinity in protein–protein complexes
Elizaveta Alexandrovna Bogdanova,
Valery Nikolaevich Novoseletsky
Abstract:Determining binding affinities in protein–protein and protein–peptide complexes is a challenging task that directly impacts the development of peptide and protein pharmaceuticals. Although several models have been proposed to predict the value of the dissociation constant and the Gibbs free energy, they are currently not capable of making stable predictions with high accuracy, in particular for complexes consisting of more than two molecules. In this work, we present ProBAN, a new method for predicting binding… Show more
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