<scp>PPAR</scp>γ activation inhibits cerebral arteriogenesis in the hypoperfused rat brain

Duelsner, André; Gatzke, Nora; Hillmeister, Philipp; Gläser, Johanna; Zietzer, Andreas; Nagorka, Stephanie; Janke, Dieter; Pfitzner, J.; Stawowy, Philipp; Meýborg, Heike; Persson, Anja Bondke; Buschmann, Ivo

doi:10.1111/apha.12179

Cited by 7 publications

(6 citation statements)

References 92 publications

(189 reference statements)

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“…STAT3 was assessed in a sample of rat’s brain homogenate [ 42 ] and CSF [ 66 ] according to the instructions provided by manufacturers of (E-EL-0118) ELISA assay Kits from Elabscience Biotechnology Inc, Wuhan, China. The level of PPAR-gamma was also quantified in brain homogenate [ 42 ] and CSF [ 67 ] using an (E-EL-R0724) ELISA kit from Elabscience Biotechnology Inc, Wuhan, China. The values expressed nM/µg protein in brain homogenate and ng/mL in CSF.…”

Section: Methodsmentioning

confidence: 99%

Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism

et al. 2022

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Autism spectrum disorder is a neurodevelopmental disorder marked by repetitive behaviour, challenges in verbal and non-verbal communication, poor socio-emotional health, and cognitive impairment. An increased level of signal transducer and activator of transcription 3 (STAT3) and a decreased level of peroxisome proliferator-activated receptor (PPAR) gamma have been linked to autism pathogenesis. Guggulsterone (GST) has a neuroprotective effect on autistic conditions by modulating these signalling pathways. Consequently, the primary objective of this study was to examine potential neuroprotective properties of GST by modulating JAK/STAT and PPAR-gamma levels in intracerebroventricular propionic acid (ICV PPA) induced experimental model of autism in adult rats. In this study, the first 11 days of ICV-PPA injections in rats resulted in autism-like behavioural, neurochemical, morphological, and histopathological changes. The above modifications were also observed in various biological samples, including brain homogenate, CSF, and blood plasma. GST was also observed to improve autism-like behavioural impairments in autistic rats treated with PPA, including locomotion, neuromuscular coordination, depression-like behaviour, spatial memory, cognition, and body weight. Prolonged GST treatment also restored neurochemical deficits in a dose-dependent manner. Chronic PPA administration increased STAT3 and decreased PPAR gamma in autistic rat brain, CSF, and blood plasma samples, which were reversed by GST. GST also restored the gross and histopathological alterations in PPA-treated rat brains. Our results indicate the neuroprotective effects of GST in preventing autism-related behavioural and neurochemical alterations.

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Section: Methodsmentioning

confidence: 99%

Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism

et al. 2022

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“…Vascular regeneration is a complex process, which is influenced by many molecular pathways (Hillmeister & Persson , Duelsner et al . ). Increased endovascular fluid shear stress leads to endothelial activation and leucocyte recruitment.…”

Section: Discussionmentioning

confidence: 97%

“…Counterpulsation treatment not only stimulates therapeutic arteriogenesis via augmentation of fluid shear stress (Buschmann et al 2009(Buschmann et al , 2016, but also stabilizes telomeres of circulating PBMCs. Vascular regeneration is a complex process, which is influenced by many molecular pathways (Hillmeister & Persson 2012, Duelsner et al 2013. Increased endovascular fluid shear stress leads to endothelial activation and leucocyte recruitment.…”

Section: Discussionmentioning

confidence: 99%

Acute physical exercise and long‐term individual shear rate therapy increase telomerase activity in human peripheral blood mononuclear cells

et al. 2016

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“…Furthermore, antidiabetic drugs may impair endogenous mechanisms that normally compensate vessel occlusions (Duelsner et al . ) and may affect LTL as well.…”

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confidence: 99%