PCAT‐1′ s role in wound healing impairment: Mitochondrial dysfunction and bone marrow stem cell differentiation inhibition via PKM2/β‐catenin pathway and its impact on implant osseo‐integration
Tianzheng Deng,
Qian Liu,
Ying Li
et al.
Abstract:This study focused on unravelling the role of PCAT‐1 in wound‐healing process, particularly its impact on regenerative and osteogenic abilities of mesenchymal stem cells (MSCs). We delved into how PCAT‐1 regulates mitochondrial oxidative phosphorylation (OXPHOS) and interacts with pivotal molecular pathways, especially β‐catenin and PKM2, using human bone marrow‐derived MSCs. MSCs were cultured under specific conditions and PCAT‐1 expression was modified through transfection. We thoroughly assessed several cri… Show more
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