<scp>PBK</scp>/<scp>TOPK</scp> expression in non‐small‐cell lung cancer: its correlation and prognostic significance with <scp>K</scp>i67 and p53 expression

Lei, Bin; Liu, Shuguang; Qi, Wenjuan; Zhao, Yunfei; Li, Yumei; Lin, Nan; Xu, Xiangdong; Chen, Zhi; Jiazhuan, Mei; Yan, Zhimin; Wan, Lei; Shen, Hong

doi:10.1111/his.12215

Cited by 64 publications

(56 citation statements)

References 37 publications

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“…Interestingly, there was a positive correlation between TOPK expression and mutant p53 expression in lung adenocarcinoma tissues. Furthermore, Kaplan-Meier survival analysis demonstrated that PBK/TOPK and mutant p53 were associated with a poor prognosis, and the correlation between TOPK and mutant p53 also affected the prognosis, which confirmed the primary report that TOPK correlated with p53 in non-small cell lung cancer [19]. Thus, combined detection of TOPK and mutant p53 by IHC will be beneficial in evaluating the prognosis of lung adenocarcinoma.…”

Section: Discussionsupporting

confidence: 73%

“…For example, TOPK is involved with highly proliferative cells and tissues and is highly expressed in many types of tumors such as lymphoma, leukemia, breast cancer, Ewing sarcoma, and colorectal cancer [6][7][8][9][10]. High TOPK expression can promote cell proliferation [11][12][13] and prevent apoptosis [14,15] and is associated with a poor prognosis [16][17][18][19]. Moreover, TOPK expression may play an important role in the progress of cytokinesis and inflammation [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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PBK/TOPK expression correlates with mutant p53 and affects patients' prognosis and cell proliferation and viability in lung adenocarcinoma

Lei

Zhao

et al. 2015

Human Pathology

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

PBK/TOPK expression correlates with mutant p53 and affects patients' prognosis and cell proliferation and viability in lung adenocarcinoma

Lei

Zhao

et al. 2015

Human Pathology

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“…As PU value become higher, the corresponding protein expression intensity get stronger. Our previous studies have proved that this method can ensure the results more precisely and scientifically (Bai et al, 2009;Xu et al, 2013;Wan et al, 2013;Lei et al, 2013).…”

Section: Discussionmentioning

confidence: 92%

TGF-β1 Protein Expression in Non-Small Cell Lung Cancers is Correlated with Prognosis

Huang¹,

Liu²,

Qi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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To investigate the expression intensity and prognostic significance of TGF-β1 protein in non-small cell lung cancer (NSCLC), immunohistochemistry was carried out in 194 cases of NSCLC and 24 cases of normal lung tissues by SP methods. The PU (positive unit) value was used to assess the TGF-β1 protein expression in systematically selected fields under the microscope with Leica Q500MC image analysis. We found that the TGF-β1 PU value was nearly two-fold higher in NSCLC than in normal lung tissues (p=0.000), being associated with TNM stages (p=0.000) and lymph node metastases (p=0.000), but not to patient age, gender, smoking history, tumor differentiation, histological subtype and tumor location (P>0.05). Univariate analysis indicated that patients with high TGF-β1 protein expression and lymph node metastases demonstrated a poor prognosis (both p=0.000, ). Multivariate analysis showed that TGF-β1 protein expression (RR = 2.565, p=0.002) and lymph node metastases (RR=1.874, p= 0.030) were also independent prognostic factors. Thus, TGF-β1 protein expression may be correlated to oncogenesis and serve as an independent prognostic biomarker for NSCLC.

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“…The PD-L1 and P53 expression in tumor tissue were detected by IHC, as described in previous studies (5,11). In our studies, IHC was performed using a rabbit monoclonal anti-PD-L1 antibody (E1L3N™, Cell Signaling Technology, Danvers, MA, USA; dilution 1:200) and rabbit monoclonal antibodies to P53 (1:50, DAKO, Glostrup, Denmark) to determine expression.…”

Section: Immunohistochemistry and Staining Interpretationmentioning

confidence: 99%

Correlation and prognostic significance of PD-L1 and P53 expression in resected primary pulmonary lymphoepithelioma-like carcinoma

Zhang

Wang

et al. 2018

J. Thorac. Dis.

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Background: Aberrant expression of programmed cell death-ligand 1 (PD-L1) and protein 53 (P53) has been observed in various malignancies, and recently, the mechanism of PD-L1 regulation by P53 has been elucidated. We aimed to explore possible correlations between PD-L1 and P53 expression and the prognosis of patients with resected pulmonary lymphoepithelioma-like carcinoma (LELC). Methods: A total of 67 consecutive patients with primary pulmonary LELC who underwent radical resection from January 2003 to December 2014 were enrolled in our study. Membranous PD-L1 and nuclear P53 expression were detected by immunohistochemical staining (IHC). Results: Positive expression of PD-L1 in tumor cells (TCs), PD-L1 in tumor-infiltrating lymphocytes (TILs) and P53 was investigated in 44 patients (65.7%), 37 patients (55.2%), and 34 patients (50.7%), respectively. Using univariate and multivariable analysis, both PD-L1 (+) in TCs and P53 (+) were observed to be significantly independent prognostic factors associated with longer disease-free survival (DFS, P=0.037 and 0.039, respectively), along with early stage LELC (P=0.037), but had no association with overall survival (OS) (P>0.05). In the P53 (+) group, the rate of patients with PD-L1 (+) in TCs was significantly higher than in the P53 (−) group (85.3% vs. 45.5%, P=0.001). In addition, among the 45 patients who underwent adjuvant chemotherapy, DFS was significantly longer in patients with either PD-L1 (+) in TCs or P53 (+) (P=0.036 and 0.044, respectively).Conclusions: PD-L1 and P53 may be potential therapeutic targets for primary pulmonary LELC. PD-L1 (+) in TCs and P53 (+) were reliable predictors for longer DFS and benefits from adjuvant therapy in resected cases. Routine detection of these two indices in lung LELC may be warranted.

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PBK/TOPK expression in non‐small‐cell lung cancer: its correlation and prognostic significance with Ki67 and p53 expression

Abstract: PBK/TOPK expression is positively correlated with Ki67 and p53 expression, and can be used as an independent prognostic factor in NSCLC.

Cited by 64 publications

References 37 publications

PBK/TOPK expression correlates with mutant p53 and affects patients' prognosis and cell proliferation and viability in lung adenocarcinoma

PBK/TOPK expression correlates with mutant p53 and affects patients' prognosis and cell proliferation and viability in lung adenocarcinoma

TGF-β1 Protein Expression in Non-Small Cell Lung Cancers is Correlated with Prognosis

Correlation and prognostic significance of PD-L1 and P53 expression in resected primary pulmonary lymphoepithelioma-like carcinoma

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