<scp>PARP</scp>‐1/<scp>PAR</scp> Activity in Cultured Human Lens Epithelial Cells Exposed to Two Levels of <scp>UVB</scp> Light

Cencer, Caroline; Chintala, Shravan K.; Townsend, Tenira J.; Feldmann, Daniel P.; Awrow, Mirna; Putris, Nahrain; Geno, Mason; Donovan, Maria G.; Giblin, Frank J.

doi:10.1111/php.12814

Cited by 8 publications

(6 citation statements)

References 78 publications

(105 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, UVC can induce neutrophil extracellular traps cell death (NETosis) and apoptosis simultaneously in neutrophil from human peripheral blood, with a predominance of apoptosis at low UV dose and an increase of NETosis at higher dose 27 . PARP-1 has been found to play a role in protecting human lens epithelium against low levels of UVB light, and the authors present the possibly that PARP may trigger cell death following a toxic level of radiation 28 . Also, the protein AIF has been shown to be involved in UVB-induced caspase-independent cell death in Jurka T Cell 29 .…”

Section: Introductionmentioning

confidence: 99%

Apoptosis, the only cell death pathway that can be measured in human diploid dermal fibroblasts following lethal UVB irradiation

Gary

Rochette

2020

Sci Rep

View full text Add to dashboard Cite

Ultraviolet radiation (UVR) is a major environmental genotoxic agent. In skin, it can lead to the formation of mutagenic DNA damage. Several mechanisms are in place to prevent the conversion of these DNA damage into skin cancer-driver mutations. An important mutation prevention mechanism is the programmed cell death, which can safely dispose of the damaged cells. Apoptosis is the most studied and best characterised programmed cell death, but an increasing amount of new cell death pathways are emerging. Using different pharmacological cell death inhibitors and antioxidants, we have evaluated the implication of apoptosis, necroptosis, ferroptosis and parthanatos in UVB-induced cell death in human diploid dermal fibroblasts. Our results show that apoptosis is the only known cell death mechanism induced by UVB irradiation in fibroblasts. We also showed that lethal UVB irradiation induces a PARP-dependent drastic loss of cellular metabolic activity caused by an overused of NAD+.

show abstract

Section: Introductionmentioning

confidence: 99%

Apoptosis, the only cell death pathway that can be measured in human diploid dermal fibroblasts following lethal UVB irradiation

Gary

Rochette

2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Evidence for perturbation by a stressor: There are studies demonstrating that increased DNA strand breaks can result from exposure to multiple stressor types including ionizing & non-ionizing radiation, chemical agents, and oxidizing agents (EPRI, 2014;Hamada, 2014;Cencer et al, 2018;Yang et al, 1998).…”

Section: Level Of Biological Organization Molecularmentioning

confidence: 99%

Oxidative DNA damage leading to chromosomal aberrations and mutations

2023

OECD Series on Adverse Outcome Pathways

View full text Add to dashboard Cite

This Adverse Outcome Pathway (AOP) on Oxidative DNA damage leading to chromosomal aberrations and mutations has been developed under the auspices of the OECD AOP Development Programme, overseen by the Extended Advisory Group on Molecular Screening and Toxicogenomics (EAGMST), which is an advisory group under the Working Party of the National Coordinators for the Test Guidelines Programme (WNT) and the Working Party on Hazard Assessment (WPHA).The AOP has been reviewed for compliance with the AOP development principles following the EAGMST coaching approach. The scientific review was subsequently conducted by the scientific journal Environmental and Molecular Mutagenesis (EMM), following the OECD AOP review principles outlined in the Guidance Document on the scientific review of AOPs. This AOP was endorsed by the WNT and the WPHA on 17 February 2023 Through endorsement of this AOP, the WNT and the WPHA express confidence in the scientific review process that the AOP has undergone and accept the recommendation of the EAGMST that the AOP be disseminated publicly. Endorsement does not necessarily indicate that the AOP is now considered a tool for direct regulatory application. The OECD's Chemicals and Biotechnology Committee agreed to declassification of this AOP on May 5 th , 2023. This document is being published under the responsibility of the OECD's Chemicals and Biotechnology Committee.The outcome of the scientific review is publicly available in the AOP-Wiki at the following link: [scientific review].

show abstract

“…PARP inhibitors might also be beneficial in the treatment of photoreceptor degeneration in hereditary retinal dystrophies or glaucoma [ 108 , 109 ]. Moreover, preclinical studies suggest that PARP inhibitors have a protective role against factors contributing to the development of age- or diabetes-related cataract [ 110 , 111 ]. A common ophthalmic side effect in patients receiving PARP inhibitors is conjunctivitis.…”

Section: Reviewmentioning

confidence: 99%

Potential Ophthalmological Side Effects Induced by Anti-Neoplastic Regimens for the Treatment of Genitourinary Cancers: A Review

Sakellakis¹,

Spathas²,

Tsaousis³

et al. 2022

Cureus

View full text Add to dashboard Cite

The outcomes of patients with genitourinary (GU) cancers have been steadily improving in recent years. Novel therapies have entered our armamentarium, while several other regimens are currently being studied in clinical trials. This recent explosion of new agents has improved patient survival and the quality of life for patients, but has also significantly increased the frequency of several side effects. The current review will focus on the potential ocular adverse reactions of GU neoplastic treatments. The broad spectrum of manifestations of ocular toxicity underscores the uniqueness and complexity of the anatomic, physiologic, and metabolic features of the human eye. Most side effects are mild in severity and transient, but some can be severe, disabling, and irreversible. Clinicians should be aware of complications that might be vision threatening and impact the patient's quality of life. In this review, we focused on the ocular toxicity of the antineoplastic regimens that are currently used for the treatment of GU, including prostate cancer, bladder cancer, renal cell carcinoma, testicular cancer, pheochromocytoma, adrenocortical carcinoma, and penile cancer.

show abstract

PARP‐1/PAR Activity in Cultured Human Lens Epithelial Cells Exposed to Two Levels of UVB Light

Cited by 8 publications

References 78 publications

Apoptosis, the only cell death pathway that can be measured in human diploid dermal fibroblasts following lethal UVB irradiation

Apoptosis, the only cell death pathway that can be measured in human diploid dermal fibroblasts following lethal UVB irradiation

Oxidative DNA damage leading to chromosomal aberrations and mutations

Potential Ophthalmological Side Effects Induced by Anti-Neoplastic Regimens for the Treatment of Genitourinary Cancers: A Review

Contact Info

Product

Resources

About