PANoptosis induced by inflammatory cytokines promotes salivary glands radiation injury
Yi Qu,
Dan Li,
Guanzheng Chen
et al.
Abstract:ObjectiveSalivary glands are frequently damaged in patients undergoing radiotherapy for head and neck cancer. Whether PANoptosis, which is characterized by pyroptosis, apoptosis, and necroptosis, occurs during radiation injury to the salivary glands and its role remain unclear.Materials and MethodsRadiation‐induced injury models of mouse submandibular gland, as well as primary acinar cells and HSG cell lines were established to determine the presence of radiation‐induced PANoptosis. Several programmed cell dea… Show more
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