OP21.09: A proposal for a new Doppler parameter: the posterior cerebral artery‐derived cerebroplacental ratio 3

Abstract

Short oral presentation abstracts(S100) and Specific Neuronal Enolasa (SNE) were measured in cord blood and the following neonatal outcomes were recorded: Apgar score at 1 and 5 minutes, admission of newborn in neonatal unit, days of admission in neonatal unit, respiratory distress syndrome, periventricular leukomalacia, hyaline membrane disease, altered neurological examination, more than 2 days of digestive intolerance, necrotizing enterocolitis, sepsis, BPD, meningitis, retinopathy and intraventricular hemorrghae. Results: GA at delivery was 33,05 (+/− 2 weeks) in IUGR and 35,1 (+/− 2 weeks) in controls (p = 0.08). Cord blood S100b values were similar in cases and controls (1,32 μg/L vs 1,38 μg/L). Cord blood SNE levels were higher in IUGR fetuses (25,2μg/L vs 13,16 μg/L) than in controls (p < 0.05). SNE value in arterial cord blood differed significantly (p < 0.05) in IUGR fetuses with following neonatal complications: worse Apgar score at 1 minute (Spearman coefficient correlation 0,49), admission of newborn in neonatal unit (20,3 μg/L vs 13,16 μg/L), days of admission in neonatal unit (Spearman coefficient correlation 0,45), periventricular leukomalacia (17,01 μg/L vs 13,16 μg/L), respiratory distress syndrome (16,76 μg/L vs 13,16 μg/L) and hyaline membrane disease (15,53 μg/L vs 13,16 μg/L).Conclusions: SNE was increased in IUGR and correlated with a higher risk of neonatal morbidity, suggesting a potential value of this biomarker for prognostic or classification purposes. OP21.07Cardiovascular changes in intrauterine growth restricted fetuses