On‐Chip Differentiation of Hepatic Cords with Radial Flow
Alan Raj Jeffrey Rajendran,
Sakina Bensalem,
Antonietta Messina
et al.
Abstract:Due to a more physiological reproduction of the in vivo situation, liver‐on‐a‐chip devices in recent studies have shown higher sensitivity and accuracy for hepatotoxicity testing compared to traditional in vitro liver models. In this context, this work presents an original microfluidic device mimicking 3D hepatic cords organized radially, like in the liver lobule. Ten cell‐culture chambers seeded at a high density are disposed with a parallelized flow that emulates blood flow from the portal triad to the centr… Show more
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