<scp>NT‐proBNP</scp>and cardiac troponin I concentrations in dogs with tick paralysis caused by<i>Ixodes holocyclus</i>

Nicolson, Geoff; McGrath, Alh; Webster, R. E.; Li, Jessica; Kaye, Susan A.; Malík, Richard; Beijerink, Niek

doi:10.1111/avj.12468

Cited by 4 publications

(5 citation statements)

References 52 publications

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“…Echocardiography is currently the preferred method to assess structural and functional cardiac disease, 42 and the present study suggests that cardiac function may play a role in the development of cachexia in debilitated green sea turtles. To more clearly understand the link between cachexia and cardiac function in green sea turtles, the use of specialised biomarkers to assess myocyte damage and preload 43 in affected animals would be of interest.…”

Section: Discussionmentioning

confidence: 99%

The use of echocardiography as a health assessment tool in green sea turtles (Chelonia mydas)

March

Marshall

Swan³

et al. 2020

Aust Veterinary J

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There are limited techniques available to assess the health of sea turtles as physical examination has little correlation to clinical findings, and blood reference intervals are broad and provide limited prognostic significance. Advances in the portability of ultrasound machines allow echocardiography to be increasingly used in the health assessments of wild animals. This study performed blood analysis and echocardiograms on 11 green sea turtles upon admission to a rehabilitation clinic and six animals before release. Significant differences were seen between groups, with admission animals having significantly smaller diameters of the cavum arteriosum at systole and diastole, smaller E‐waves and an increased fractional shortening. Pre‐release animals displayed significant increases in the maximum blood velocities of both the pulmonary artery and the left aorta. Significant negative correlations were seen between fractional shortening and uric acid and between the velocity time integral of the pulmonary artery and urea. The pulmonary artery velocity time integral was also significantly correlated to the E wave. Furthermore, there was asynchrony between the cavum arteriosum and the cavum pulmonale and the detection of a parasitic granuloma in the ventricular outflow tract of one animal. Overall, the results suggest that cardiac function in stranded green sea turtles is significantly impaired and that echocardiography has applications in the health assessments of green sea turtles.

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Section: Discussionmentioning

confidence: 99%

The use of echocardiography as a health assessment tool in green sea turtles (Chelonia mydas)

March

Marshall

Swan³

et al. 2020

Aust Veterinary J

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“…A study of 46 dogs with TP demonstrated low protein pulmonary oedema due to reversible diastolic dysfunction causing left-sided congestive heart failure ( 16 ). However, a subsequent study of 80 dogs with TP and 31 healthy control dogs failed to show an increase in the biomarker cardiac troponin I, suggesting an absence of myocardiocyte injury in animals affected with the disease ( 103 ).…”

Section: Management Of the Ventilated Patientmentioning

confidence: 99%

Mechanical ventilation in dogs and cats with tick paralysis

O'Keeffe¹,

Donaldson²

2023

Front. Vet. Sci.

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Respiratory failure from tick paralysis (TP) is an important cause of mortality in cats and dogs in Australia, occurring from a combination of respiratory muscle paralysis, upper respiratory tract obstruction and pulmonary disease. Patients may require positive-pressure ventilation in management of any combination of hypoxemia, hypoventilation or respiratory fatigue, but may also require airway management due to laryngeal paralysis. No single ventilation strategy is recommended due to the heterogenous disease presentations. Lung protective ventilation should be used in patients with pulmonary disease. Due to local and systemic effects of TP, patients are at higher risk of complications such as aspiration pneumonia and corneal ulceration and may have additional intravenous fluid and nutritional considerations. Treatment with hyperimmune serum is associated with improved outcomes. Prognosis is considered good with documented survival to discharge (STD) of 52.6–77% for animals with TP ventilated with lung disease and 90.5% for animals without lung disease. Median reported duration of ventilation for TP ranges from 23 to 48 h (range 3 h−10 days). The severity of individual neuromuscular signs and the presence of associated conditions such as aspiration pneumonia and laryngeal paralysis may necessitate longer periods of mechanical ventilation. This review aims to summarize the current recommendations regarding indications, management and prognosis of cats and dogs undergoing MV for TP and to identify areas for future research.

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“…Most importantly, it is necessary to delay degradation (like hemolysis, for instance) during collection procedures and transportation to a laboratory. Furthermore, samples have to be centrifuged and kept under refrigeration immediately after collection [ 5 , 9 , 31 , 34 - 37 ]. Sample storage methods also greatly influence the values of NT-proBNP in serum.…”

Section: Laboratory Evaluationmentioning

confidence: 99%

N-terminal-pro brain natriuretic peptides in dogs and cats: A technical and clinical review

Lima¹,

Ferreira²

2017

Vet World

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Biomarkers are quantitative indicators of biological processes performed by an organ or system. In recent years, natriuretic peptides (NPs) have emerged as important tools in the diagnosis and therapeutic monitoring of heart diseases. Research has shown that serum and plasma levels of N-terminal pro brain NP (NT-proBNP) in dogs and cats are the only biomarkers that afford to diagnose and monitor congestive processes and, indirectly, the myocardial function of small animals. The present review discusses the peer-reviewed specialized literature about NT-proBNP and presents and compares the potential clinical applications of this NP in veterinary medicine of small animals, considering diagnosis, follow-up, and prognosis of myocardial or systemic diseases. The relevance of NT-proBNP is associated with sample stability, easy determination in laboratory, sensitivity, accuracy, and the possibility to analyze myocardial function. These advantages are specially important when NT-proBNP is compared with other cardiac biomarkers, mostly those that indicate the integrity of the myocardial cell. Fast NT-proBNP assays are marketed today and may be used in association with complementary tests. Together, these methods are an important source of information in differential diagnosis of heart and lung diseases as well in the early diagnosis of cardiopathy in dogs and cats, proving valuable tools in treatment and prognosis.

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NT‐proBNPand cardiac troponin I concentrations in dogs with tick paralysis caused byIxodes holocyclus

Cited by 4 publications

References 52 publications

The use of echocardiography as a health assessment tool in green sea turtles (Chelonia mydas)

The use of echocardiography as a health assessment tool in green sea turtles (Chelonia mydas)

Mechanical ventilation in dogs and cats with tick paralysis

N-terminal-pro brain natriuretic peptides in dogs and cats: A technical and clinical review

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