NMR‐identification of the interaction between BRCA1 and the intrinsically disordered monomer of the Myc‐associated factor X
Ludovica Martina Epasto,
Christopher Pötzl,
Herwig Peterlik
et al.
Abstract:The breast cancer susceptibility 1 (BRCA1) protein plays a pivotal role in modulating the transcriptional activity of the vital intrinsically disordered transcription factor MYC. In this regard, mutations of BRCA1 and interruption of its regulatory activity are related to hereditary breast and ovarian cancer (HBOC). Interestingly, so far, MYC's main dimerization partner MAX (MYC‐associated factor X) has not been found to bind BRCA1 despite a high sequence similarity between both oncoproteins. Herein, we show t… Show more
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