<scp>NLRP2</scp> in health and disease

Zhang, Tongtong; Xing, Fei; Qu, Mingcui; Yang, Zhihu; Liu, Yafei; Yao, Yongchao; Xing, Na

doi:10.1111/imm.13699

Cited by 2 publications

(2 citation statements)

References 99 publications

(119 reference statements)

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“…NLRP2 has diverse functions, including IFN inhibition and inflammation promotion outside of inflammasome activation, varying across cell types. Further biochemical research is required to fully comprehend the activation, assembly, and functional role of NLRP2 [150].…”

Section: Inflammasome In Multiple Sclerosismentioning

confidence: 99%

“…NLRP2, while capable of inflammasome formation, may also exhibit anti-inflammatory effects. In 2004, Bruey et al have suggested that NLRP2 functions as a modulator of NF-κB activation in macrophages, emphasizing its significance in regulating inflammatory signals across different cell types [150]. Although AIM2's involvement in MS has been proposed, limited information exists regarding its specific role in this autoimmune condition [154].…”

Section: Inflammasome In Multiple Sclerosismentioning

confidence: 99%

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Inflammasome Molecular Insights in Autoimmune Diseases

Neamțu,

Bild,

Vasincu

et al. 2024

CIMB

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Autoimmune diseases (AIDs) emerge due to an irregular immune response towards self- and non-self-antigens. Inflammation commonly accompanies these conditions, with inflammatory factors and inflammasomes playing pivotal roles in their progression. Key concepts in molecular biology, inflammation, and molecular mimicry are crucial to understanding AID development. Exposure to foreign antigens can cause inflammation, potentially leading to AIDs through molecular mimicry triggered by cross-reactive epitopes. Molecular mimicry emerges as a key mechanism by which infectious or chemical agents trigger autoimmunity. In certain susceptible individuals, autoreactive T or B cells may be activated by a foreign antigen due to resemblances between foreign and self-peptides. Chronic inflammation, typically driven by abnormal immune responses, is strongly associated with AID pathogenesis. Inflammasomes, which are vital cytosolic multiprotein complexes assembled in response to infections and stress, are crucial to activating inflammatory processes in macrophages. Chronic inflammation, characterized by prolonged tissue injury and repair cycles, can significantly damage tissues, thereby increasing the risk of AIDs. Inhibiting inflammasomes, particularly in autoinflammatory disorders, has garnered significant interest, with pharmaceutical advancements targeting cytokines and inflammasomes showing promise in AID management.

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Section: Inflammasome In Multiple Sclerosismentioning

confidence: 99%

Section: Inflammasome In Multiple Sclerosismentioning

confidence: 99%

Inflammasome Molecular Insights in Autoimmune Diseases

Neamțu,

Bild,

Vasincu

et al. 2024

CIMB

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Deciphering Complex Regions within the Human Genome and Unraveling Their Critical Biomedical Regulatory Functions

Du,

Li,

Zhu

et al. 2024

Preprint

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Background: Nuclear genomic DNA plays a crucial role in individual development and phenotype determination. The genetic landscape within populations exhibits significant heterogeneity, contributing to diverse human traits. Current studies of human genome heterogeneity often focus on specific segments of high-frequency phenotype-associated sequences or structurally complex regions. Therefore, to overcome the limitations of previous studies and more directly explore population heterogeneity, it is essential to study the entire genome rather than focusing only on known phenotype-associated regions. Results: Using set theory, we have clearly defined Complex Regions (Complex_Region) by integrating pan-genome datasets, covering about 8.1% of the human genome. These regions exhibit high sequence diversity and nonrandom long continuous fragments (≥450kb), thus reflecting population genetic complexity. Our enrichment analysis revealed that genes within Complex_Region are primarily involved in immunity and metabolism, indicating chromosome-specific functional enrichment. Notably, immune genes are mainly located on chromosomes 6 and 19, which are closely associated with disease occurrence. Moreover, these regions are enriched for human phenotype-related signals and tumor somatic mutations, providing novel insights for large-scale cohort studies. We also detected ancient viral sequences, particularly ~9.47 kb human endogenous retroviruses (HERV) insertion sequence NC_022518, which is diverse in humans but remains conserved across primates, to be implicated in regulating bodily functions and various diseases. Conclusions: Our study highlights the biomedical importance of Complex_Region by revealing associations among genotypes, environment, and phenotypes. This enhances our understanding of life regulation and phenotype shaping, highlighting the role of these regions in immunity, metabolism, and disease association.

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NLRP2 in health and disease

Cited by 2 publications

References 99 publications

Inflammasome Molecular Insights in Autoimmune Diseases

Inflammasome Molecular Insights in Autoimmune Diseases

Deciphering Complex Regions within the Human Genome and Unraveling Their Critical Biomedical Regulatory Functions

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