Ni₂P Nanosheets: A High Catalytic Activity Platform for Electrochemical Detection of Acetaminophen

Abstract

Main observation and conclusion Accurate determination of acetaminophen concentration is essential for studying the metabolic status of acetaminophen in clinical practice. In this study, nickel phosphide was used for electrochemical detection of acetaminophen for the first time. An electrochemical acetaminophen sensor based on Ni2P nanosheets was successfully constructed and the sensor showed many convincing properties: (a) a good linear range (0.5 μmol/L—4.5 mmol/L); (b) a moderate sensitivity (131.1 μA·mmol–1·L·cm–2); (c) a low detection limit (0.107 μmol/L). In addition, the sensor also showed excellent selectivity, robust stability and reliable repeatability. Further experiments demonstrate that the prepared sensor can be used for quantitative detection of acetaminophen in commercial medical drugs.

Electrochemical Sensors Based on Transition Metal Materials for Phenolic Compound Detection

“…By DPV, two well-separated oxidation peaks were observed (Figure 6c), and the corresponding electrochemical oxidation currents of the two isomers increased linearly with concentration over a wide concentration range [85]. Other monometallic TMPs, such as Ni 2 P nanosheets [86] and nitrogen and iron phosphides doped carbon nanotubes (N/FeP-CNT) [83], have also demonstrated efficiency as electrode materials for the electrochemical detection of acetaminophen and simultaneous detection of dihydroxybenzoic acid isomers, respectively.…”

Au nanoparticle-decorated Ni2P nanosheet arrays with porous grids for electroanalytical hydroquinone sensing

“…TMPs are a class of interstitial compounds formed by phosphorus and transition metals. [10][11][12] As a multifunctional nanomaterial, TMPs have been widely applied in the fields of electrocatalysis, 13,14 imaging, 15,16 energy storage 17,18 and photoelectric detection, 19,20 which greatly stimulates the enthusiasm of researchers. Nickel phosphide (Ni x P), a typical representative of TMPs, exhibit an excellent catalytic capacity, which can be regulated by changing the topological structure and adjusting the ratio of nickel to phosphorus.…”