We report here the case of a tracheal and end bronchial infection by the mucormycosis fungi, on a young patient admitted in the ICU for a heatstroke. Several undercurrent pathologies were associated with his condition. Secondary to a multi-organ failure, he received an emergency hepatic transplantation and an immunosuppress or treatment was implemented. Following that, he developed a mucormycosis infection, diagnosed after endotracheal sputum culture and fibro copy. He thus received amphotericin B and isavuconazole in intravenous perfusions and Aerobe, but surgeons decide not to operate because of a too big surgical risk, and a operation considered as impossible to perform Indeed, it is important to know the physiopathology very well and to be able to detect the risk factors to develop this infection to get a chance of a successful outcome. Treatment consist in a combination of an early antifungal treatment, the correction of risk factors, and sometime surgical sanction. However, it is essential to realize that this is correlated with and important morbidity/mortality rate.