<scp>MRP</scp>1 expression in bronchoalveolar lavage cells in subjects with lung cancer who were chronically exposed to arsenic

Recio-Vega, Rogelio; Dena-Cazares, Jose Angel; Peña, Jorge Luis Ramirez-de la; Jacobo-Ávila, Antonio; Portales-Castanedo, Arnulfo; Gallegos‐Arreola, Martha Patricia; Ocampo-Gomez, Guadalupe; Michel-Ramirez, Gladis

doi:10.1002/em.21960

Cited by 8 publications

(10 citation statements)

References 62 publications

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“…In Mexico, a case-control study investigated whether As could influence multidrug resistance-associated protein-1 (MRP1) expression, which has a protective role against arsenic. This study demonstrated significant reduction of MRP1 expression in bronchoalveolar lavage (BAL) cells in lung cancer patients with levels of >50 μg/L when compared with the controls with similar As levels (p=0.02) (Recio-Vega et al, 2015a). This may increase intracellular toxic compounds in lung cells, increasing lung cancer risk.…”

Section: Lung Cancermentioning

confidence: 72%

Health effects of arsenic exposure in Latin America: An overview of the past eight years of research

Khan

Chakraborty

Bundschuh

et al. 2020

Science of The Total Environment

103

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Studies conducted over the past eight years in Latin America (LA) have continued to produce new knowledge regarding health impacts of arsenic (As) in drinking water. We conducted a systematic review of 92 peer-reviewed English articles published between 2011 and 2018 to expand our understanding on these health effects. Majority of the LA studies on As have been conducted in Chile and Mexico. Additional data have emerged from As-exposed populations in Argentina,

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Section: Lung Cancermentioning

confidence: 72%

Health effects of arsenic exposure in Latin America: An overview of the past eight years of research

Khan

Chakraborty

Bundschuh

et al. 2020

Science of The Total Environment

103

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“…Lindberg et al [] reported that in a population from Bangladesh gender and age were major factors influencing As metabolism, and that women had higher As methylation efficiency than men. However, sexual difference in As methylation capacity was not observed in other studies [Chiou et al, ; Kurttio et al, ; Chen et al, ; Recio‐Vega et al, ]. This gender difference in As methylation capacity could be explained in part by the effect of estrogen.…”

Section: Discussionmentioning

confidence: 76%

Association between polymorphisms in arsenic metabolism genes and urinary arsenic methylation profiles in girls and boys chronically exposed to arsenic

Recio-Vega

Gonzalez-Cortes

Olivas-Calderón

et al. 2016

Environ and Mol Mutagen

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Disease manifestations or susceptibilities often differ among individuals exposed to the same concentrations of arsenic (As). These differences have been associated with several factors including arsenic metabolism, sex, age, genetic variants, nutritional status, smoking, and others. The present study evaluated the associations between four As metabolism-related gene polymorphisms/null genotypes with urinary As methylation profiles in girls and boys chronically exposed to As. In a total of 332 children aged 6-12 years, the frequency of AS3MT, GSTO1, GSTT1, and GSTM1 polymorphisms/null genotypes and As urinary metabolites were measured. The results revealed that total As and monomethyl metabolites of arsenic (MMA) levels were higher in boys than in girls. No differences in the frequency of the evaluated polymorphisms were found between girls and boys. In AS3MT-Met287Thr carriers, %MMA levels were higher and second methylation levels (defined as dimethylarsinic acid divided by MMA) were lower. In children with the GSTM1 null genotype, second methylation levels were higher. In boys, a positive association between the AS3MT-Met287Thr polymorphism with %MMA and between the GSTO1-Glu155del and Asv was found; whereas, a negative relationship was identified between AS3MT-Met287Thr and second methylation profiles. In girls, a positive association was found between the GSTO1-Ala140Asp polymorphism with second methylation levels. In conclusion, our data indicate that gender, high As exposure levels, and polymorphisms in the evaluated genes negatively influenced As metabolism.

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“…Thus, these efflux proteins contribute to the many physiological and pathophysiological processes influenced by these compounds, including oxidative stress. In a previous study, we reported a negative correlation between MRP1 expression and chronic arsenic exposure in subjects with lung cancer (Recio‐Vega et al, 2015). Several studies evaluating the effects of polymorphism of both efflux pumps on their function have been reported.…”

Section: Introductionmentioning

confidence: 73%

“…A cross‐sectional study was carried out, and participants were recruited from the Department of Respiratory Diseases, Mexican Institute of Social Security, Torreon, Coahuila, Mexico. The volunteers were residents of the Comarca Lagunera where higher arsenic tap water levels have been detected in the last 32 years, ranging from 10.4 to 360 ppb in 2015 (Recio‐Vega et al, 2015). The geographic area received groundwater through the local water supply, and the high As levels in the water are due, in part, to an overextraction of water from the ground for crops.…”

Section: Methodsmentioning

confidence: 99%

Association between the polymorphism of three genes involved in the methylation and efflux of arsenic (As3MT, MRP1, and P‐gp) with lung cancer in a Mexican cohort

Recio-Vega

Hernandez-Gonzalez

Michel-Ramirez

et al. 2020

J of Applied Toxicology

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Lung cancer is the most common neoplasm and the primary cause‐related mortality in developed and in most of nondeveloped countries. Epidemiological studies have demonstrated that even at low arsenic doses, the lungs are one of the main target organs and that chronic arsenic exposure has been associated with an increase in lung cancer development. Among the risk factors for cancer, arsenic methylation efficiency (As3MT) and the clearance of arsenic from cells by two members of the ATP‐binding cassette (ABC) transporter family (multidrug resistance protein 1 [MRP1] and P‐glycoprotein [P‐gp]) play an important role in processing of arsenic and decreasing its intracellular levels. This study aimed to evaluate the association between chronic exposure to arsenic with polymorphism of three proteins involved in arsenic metabolism and efflux of the metalloid in subjects with lung cancer. Polymorphism in As3MT, MRP1, and P‐gp modified the arsenic metabolism increasing significantly the AsV urinary levels. A significant association between MRP1 polymorphisms with an increase in the risk for cancer was found. The high inorganic arsenic urinary levels registered in the studied subjects suggest a reduction in the efficiency of As3MT, MRP1, and P‐gp firstly because of gene polymorphisms and secondarily because of high internal inorganic arsenic levels. MRP1 polymorphism was associated with a twofold increase in the risk of lung cancer.

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MRP1 expression in bronchoalveolar lavage cells in subjects with lung cancer who were chronically exposed to arsenic

Cited by 8 publications

References 62 publications

Health effects of arsenic exposure in Latin America: An overview of the past eight years of research

Health effects of arsenic exposure in Latin America: An overview of the past eight years of research

Association between polymorphisms in arsenic metabolism genes and urinary arsenic methylation profiles in girls and boys chronically exposed to arsenic

Association between the polymorphism of three genes involved in the methylation and efflux of arsenic (As3MT, MRP1, and P‐gp) with lung cancer in a Mexican cohort

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