Abstract:This enzyme (UlaG) catalyzes the first catabolic reaction in the ascorbate assimilation pathway, the divalent‐metal‐dependent hydrolytic lactone ring opening of
L
‐ascorbate 6‐phosphate into 3‐keto‐
L
‐gulonate 6‐phosphate. Apart from its physiologic reaction, UlaG can also cleave phosphodiester bond linkages within substrates such as cyclic nucleoside monophosphates and phosphatase‐type substrates [e.g., bis(p‐nitrophenylphosphate), bis‐pNPP]. The crystal struct… Show more
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