<scp>MMP</scp>‐8 ‐799 <scp>C</scp>&gt;<scp>T</scp> genetic polymorphism is associated with the susceptibility to chronic and aggressive periodontitis in Taiwanese

Chou, Yu-Hsiang; Ho, Ya-Ping; Lin, Ying‐Chu; Hu, Kai-Fang; Yang, Yi‐Hsin; Ho, Kuen‐Yao; Wu, Yimin; Hsi, Edward; Tsai, Chi‐Cheng

doi:10.1111/j.1600-051x.2011.01798.x

Cited by 16 publications

(24 citation statements)

References 36 publications

(70 reference statements)

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“…1 , we initially identified 142 articles. Finally we included 16 articles 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 with 24 case-control studies involving 2,724 cases and 3,438 controls. Among them, there were four polymorphisms of MMP gene included in our meta-analysis: nine on MMP -9-1562 C/T, seven on MMP -3-1171 A5/A6, four on MMP -2-753C/T, and four on MMP -8-799 C/T.…”

Section: Resultsmentioning

confidence: 99%

Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals

Weng

Yan

Jin

et al. 2016

Sci Rep

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We aimed to systematically investigate the potential association of matrix metalloproteinase (MMP)-9, -3, -2, and -8 gene polymorphisms with susceptibility to periodontitis using meta-analysis. A literature search in PubMed, Embase, and Web of Sciencewas conducted to obtain relevant publications. Finally a total of 16 articles with 24 case-control studies (nine on MMP-9-1562 C/T, seven on MMP-3-1171 A5/A6, four on MMP-2-753C/T, and four on MMP-8-799 C/T) were considered in this meta-analysis. The results based on 2,724 periodontitis patients and 3,438 controls showed that MMP-9-1562C/T, MMP-3-1171 A5/A6, and MMP-8-799C/T polymorphisms were associated with periodontitis susceptibility. No significant association was found between MMP-2-753 C/T and periodontitis susceptibility. Subgroup analyses suggested that the MMP-9-1562 C/T polymorphism reduced chronic periodontitis susceptibility and MMP-3-1171 A5/A6polymorphism increased chronic periodontitis susceptibility. In summary, current evidence demonstrated that MMP-9-753 C/Tpolymorphism reduced the risk of periodontitis, MMP-3-1171 5A/6A and MMP-8-799 C/Tpolymorphisms increased the risk of periodontitis, and MMP-2-753 C/T was not associated with risk of periodontitis.

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Section: Resultsmentioning

confidence: 99%

Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals

Weng

Yan

Jin

et al. 2016

Sci Rep

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“…, Chou et al. ) have rendered important clues to the pathogenesis of periodontal disease. However, most genetic association studies on periodontitis have usually included an individual population and a single or a few polymorphisms within a given gene, thus not capturing the complete genetic information of the region of interest (Schafer et al.…”

Section: Discussionmentioning

confidence: 99%

“…, Chou et al. ). Nevertheless, most of these studies reflect investigation of an individual polymorphism in a single gene or in a couple of genes, which makes interpretation of the results difficult, taken the complexity of the MMP family and their compensatory mechanisms.…”

Section: Introductionmentioning

confidence: 99%

MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression

Letra

Silva

Rylands

et al. 2012

J Clinic Periodontology

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Aim Matrix metalloproteinases (MMPs) play a key role in the tissue destruction characteristic of chronic periodontitis. The purpose of this study was to investigate the association of MMP and TIMP polymorphisms with chronic periodontitis in two populations. Materials and Methods Thirty-four polymorphisms spanning 12 MMP and 2 TIMP genes were genotyped in 401 individuals from Brazil (99 cases with chronic periodontitis and 302 controls), and 274 individuals from the US (70 cases and 204 controls). Individuals were considered cases if presenting at least three teeth exhibiting sites of clinical attachment loss ≥5mm in two different quadrants. Controls were characterized by absence of clinical attachment loss and no sites with probing depth >3mm. MMP3 and TIMP1 mRNA expression was evaluated in healthy and diseased periodontal tissues. Results TIMP1 showed association with chronic periodontitis in the Brazilian population (for rs5906435, P=0.0004), whereas MMP3 showed association in the US population (for rs679620, P=0.0003; and rs650108, P=0.002) and in the Brazilian population (for rs639752, P=0.005). MMP3 and TIMP1 mRNA expression was significantly higher in diseased tissues when compared to control tissues. Conclusions Our results further support a role for variations in MMP3 in chronic periodontitis and report a novel association with TIMP1. These genes may be considered additional candidate genes for chronic periodontitis.

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“…Considering the key roles of matrix metalloproteinase‐8 and tissue inhibitors of matrix metalloproteinase‐1 in periodontal tissues, it has been hypothesized that genetic variations influencing the transcription or function of these biomarkers contribute to susceptibility to generalized aggressive periodontitis. To date, only two studies have been reported of matrix metalloproteinase‐8 polymorphisms in relation to chronic periodontitis . On a genome‐wide level, no association of these polymorphisms has been found with either aggressive or chronic periodontitis.…”

Section: Possible Role Of Matrix Metalloproteinase‐8 Polymorphism In mentioning

confidence: 99%

Analysis of matrix metalloproteinases, especially MMP‐8, in gingival crevicular fluid, mouthrinse and saliva for monitoring periodontal diseases

Sorsa¹,

Gürsoy²,

Nwhator³

et al. 2015

Periodontology 2000

245

430

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Matrix metalloproteinase-8 is a promising candidate biomarker for oral fluid (gingival crevicular fluid, peri-implant sulcular fluid and saliva) and mouthrinse chair-side/point-of-care diagnostics to predict, diagnose and determine the progressive phases of episodic periodontitis and peri-implantitis, as well as to monitor the treatments and medications. Matrix metalloproteinase-8 can be used alone or together with interleukin-1beta and Porphyromonas gingivalis to calculate cumulative risk score at the subject level as a successful diagnostic tool, especially in large-scale public health surveys, in which a thorough periodontal examination is not feasible.

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MMP‐8 ‐799 C>T genetic polymorphism is associated with the susceptibility to chronic and aggressive periodontitis in Taiwanese

Abstract: These results suggested that non-smoking Taiwanese with the MMP-8 -799 T allele were associated with the risks of both CP and AgP. Further studies in other ethnic populations are necessary.

Cited by 16 publications

References 36 publications

Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals

Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals

MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression

Analysis of matrix metalloproteinases, especially MMP‐8, in gingival crevicular fluid, mouthrinse and saliva for monitoring periodontal diseases

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