MK2 inhibitor PF‐3644022 shows protective effect in mouse microglial N9 cell line induced with cigarette smoke extract
Shikha Asthana,
Shivam Kumar Pandey,
Avtar Singh Gautam
et al.
Abstract:Neuroinflammation is suggested as one of the potential links between CS‐induced neuronal dysfunction. Cigarette smoke (CS) is one of the significant contributors of neuroinflammation, consequently leading to cognitive impairment and neurodegeneration. Microglia are the key resident macrophage cells in the brain with cell surface TLR4 receptor for responding to various stress signals. The CS constituents promote inflammation and oxidative stress in microglia leading to cytotoxicity through the TLR4‐MK2 axis. Ho… Show more
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