Abstract:ObjectivePirarubicin (THP) is a widely used antitumor drug in clinical practice, but its cardiotoxicity limits its use. There is an urgent need to find drugs to alleviate the cardiotoxicity of THP. This study aimed to investigate the effect and mechanism of miR‐494‐3p on THP‐induced cardiomyocytes.MethodsTHP induced immortalized mouse cardiomyocytes HL‐1, silenced or overexpressed miR‐494‐3p. The effects of miR‐494‐3p on HL‐1 contained in THP were investigated by CCK8, flow cytometry, ROS detection, JC‐1 mitoc… Show more
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