MiR‐484 promotes nonalcoholic fatty liver disease progression in mice via downregulation of Sorbs2
Yinzhao Jia,
Hao Pan,
Jing Liu
et al.
Abstract:ObjectiveMicroRNA 484 (miR‐484) plays a pivotal role in the development and progression of different diseases and is typically described as a mitochondrial regulator. Whether miR‐484 is involved in lipid metabolism or exerts a role in nonalcoholic fatty liver disease remains unclear.MethodsmiR‐484 levels were examined in the livers of male mice fed a high‐fat diet and in hepatocytes treated with free fatty acids. Sorbin and SH3 structural domain‐containing protein 2 (Sorbs2) were identified as a novel target o… Show more
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