<scp>miR</scp>‐144‐3p represses hepatocellular carcinoma progression by affecting cell aerobic glycolysis via <scp>FOXK1</scp>

Xing, Binyu; Shen, Cunyi; Yang, Qinling; Wang, Zheng; Tan, Wenjun

doi:10.1111/iep.12468

Cited by 7 publications

(2 citation statements)

References 36 publications

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“…Cao et al [21] have found that miR-144-3p is highly expressed in thyroid cancer tissue and the silencing miR-144-3p can inhibit cell proliferation, invasion and promote cell apoptosis. Also, previous research have proven that miR-144-3p can inhibit biological behaviors like the proliferation, migration and invasion of tumor cells [21,22]. Despite extensive reporting on miR-144-3p in tumors, limited investigations have been conducted regarding its presence in colon carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Highly expressed miR-144-3p promotes the proliferation, migration and invasion of colon carcinoma cells by activating the Wnt/β-catenin signaling pathway through targeting SFRP1

Lai,

He,

Zeng

et al. 2023

J. Cancer

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Background: To investigate the influence of miR-144-3p on the proliferation, migration and invasion of colon carcinoma by targeting secreted frizzled-related protein 1 (SFRP1) as well as of the Wnt/β-catenin signaling pathway. Methods: Based on the TCGA database, the association between the expression of miR-144-3p and the clinical information and prognosis of patients with colon carcinoma was examined, and SFRP1 was selected as the target gene for further studies based on bioinformatics prediction tools. CCK8 assay, wound healing assay and transwell invasion assay were employed to examine the impact of miR-144-3p on colon carcinoma cells. The regulation of SFRP1 by miR-144-3p was investigated using a dual-luciferase reporter system, and a rescue experiment was conducted to further elucidate whether miR-144-3p promotes the migration of colon carcinoma cells through targeting SFRP1 or not. The Wnt/β-catenin signaling pathway-mediated effect of miR-144-3p in colon carcinoma was finally validated through the targeting of SFRP1. Results: The bioinformatics analysis showed that the miR-144 expression levels were substantially greater in colon carcinoma tissue than in para-carcinoma tissue and were closely with clinical stage and prognosis. The findings obtained from the trial indicated that miR-144-3p substantially expressed in colon carcinoma tissue sample and the colon carcinoma cells, and the overexpressed miR-144-3p boosted the colon carcinoma cells' proliferation, migration and invasion. The results of dual-luciferase reporter gene assay revealed that miR-144-3p targeted SFRP1, and rescue experiment was carried out and its results indicated that miR-144-3p increased colon carcinoma cells' migration through targeting SFRP1. In addition, the molecular axis of miR-144-3p/SFRP1 may over-activate the Wnt/β-catenin signaling pathway. Conclusions:The present study has identified a novel malignant biological behavior, namely the ability of miR-144-3p to enhance the proliferation, migration and invasion of colon carcinoma cells by targeting SFRP1 and activating the Wnt/β-catenin signaling pathway. Consequently, miR-144-3p emerges as a promising diagnostic and therapeutic target for colon carcinoma.

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Section: Discussionmentioning

confidence: 99%

Highly expressed miR-144-3p promotes the proliferation, migration and invasion of colon carcinoma cells by activating the Wnt/β-catenin signaling pathway through targeting SFRP1

Lai,

He,

Zeng

et al. 2023

J. Cancer

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“…In contrast, FOXK2 exerts tumor-suppressive functions in prostate cancer and medulloblastoma ( 23 ). Additionally, FOXK1 appears to regulate expression of genes involved in glucose metabolism, whereas FOXK2 regulates the DNA damage response and its repair ( 34 , 35 ).…”

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confidence: 99%

FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration

El-Mergawy,

Chafin,

Ovando-Ricardez

et al. 2024

Journal of Biological Chemistry

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CangFu Daotan decoction improves polycystic ovarian syndrome by downregulating FOXK1

Wang

Ding

et al. 2023

Gynecological Endocrinology

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miR‐144‐3p represses hepatocellular carcinoma progression by affecting cell aerobic glycolysis via FOXK1

Cited by 7 publications

References 36 publications

Highly expressed miR-144-3p promotes the proliferation, migration and invasion of colon carcinoma cells by activating the Wnt/β-catenin signaling pathway through targeting SFRP1

Highly expressed miR-144-3p promotes the proliferation, migration and invasion of colon carcinoma cells by activating the Wnt/β-catenin signaling pathway through targeting SFRP1

FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration

CangFu Daotan decoction improves polycystic ovarian syndrome by downregulating FOXK1

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