MicroRNA‐210 targets FBXO31 to inhibit tumor progression and regulates the Wnt/β‐catenin signaling pathway and EMT in esophageal squamous cell carcinoma

Abstract

Evidence from previous studies showed that the dysregulation of microRNA (miR) is frequently associated with tumor progression. The aberrant miR‐210 expression has been identified in a variety of tumors. However, its biological roles in esophageal squamous cell carcinoma (ESCC) still need further elucidation. Thus, in the current study we explore the roles of miR‐210 in ESCC progression. The findings of our study reveal that miR‐210 is down‐regulated in ESCC, which indicates poor prognosis and aggressive tumor progression. Moreover, miR‐210 restoration was found to enhance ESCC viability, invasion, and migration abilities. F‐Box only protein 31 (FBXO31) was confirmed to be one of the targets of miR‐210 in ESCC cells. Results also revealed that miR‐210 played crucial roles in regulating ESCC cell epithelial‐mesenchymal transition (EMT) and Wnt/β‐catenin signaling. In conclusion, data show that miR‐210 serves as an anti‐ESCC miR via down‐regulation of FBXO31 and regulation of EMT and Wnt signaling, suggesting that the miR‐210/FBXO31 axis may function as promising therapeutic targets and effective prognostic markers for ESCC patients.

Prognostic Potential of MicroRNAs in Glioma Patients: A Meta-Analysis

“…For example, microRNA 210 and 451a that despite being oncogenic in the case of glioma have shown to downregulate cancer cell in esophageal cancer and small cell carcinoma of the lung, respectively. 31 32 As seen in Tables 5 and 6 , all of these microRNAs are involved in pathogenesis of various tumors and thus it shows that their application as a prognostic tool would not only be limited to glioma.…”

“…MicroRNA 210 is known to target to FBXO31 and plays a role in epithelial mesenchymal transition and Wnt/β-catenin signaling 31…”

“…The downstream target of Mir-10b is Sirt1, which acts on the PTEN/PI3K/AKT signaling pathway to enhances growth of tumors 42 MicroRNA 429 Ovarian cancer It targets c-myc and PLGG1 to exert its effects in several tumors 43 MicroRNA 210 Tumor suppressor in esophageal cancer MicroRNA 210 is known to target to FBXO31 and plays a role in epithelial mesenchymal transition and Wnt/βcatenin signaling 31 MicroRNA 451a Downregulated in small cell lung cancer and colon cancer…”