MHC class III lymphocyte antigens 6 as endogenous immunotoxins: Unlocking immunotherapy in proficient mismatch repair colorectal cancer
Guido Giordano,
Massimo Pancione
Abstract:A majority of cancers, including colorectal cancer (CRC) with intact DNA mismatch repair, exhibit a paralyzed antitumor immune response and resistance to immune checkpoint inhibitors. Members of MHC class III lymphocyte antigen 6G (LY6G) encode glycosylphosphatidylinositol (GPI) proteins anchored to the membrane. Snake venom neurotoxins and LY6G proteins share a three‐finger (3F) folding domain. LY6 proteins such as LY6G6D are gaining a reputation as excellent tumor‐associated antigens that can potently inhibi… Show more
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