MHC‐DRB alleles with amino acids Val11, Phe13, and the shared epitopes promote collagen‐induced arthritis and a rapid IgG1 response in Filipino cynomolgus macaques
Hirohito Ishigaki,
Sayaka Ito,
Takako Sasamura
et al.
Abstract:Macaques are useful animal models for studying the pathogenesis of rheumatoid arthritis (RA) and the development of anti‐rheumatic drugs. The purpose of this study was to identify the major histocompatibility complex (MHC) polymorphisms associated with the pathology of collagen‐induced arthritis (CIA) and anti‐collagen IgG induction in a cynomolgus macaque model, as MHC polymorphisms affect the onset of CIA in other animal models. Nine female Filipino cynomolgus macaques were immunized with bovine type II coll… Show more
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