LncRNA RP11‐301G19.1 is required for the maintenance of vascular smooth muscle cell contractile phenotype via sponging miR‐17‐5P/ATOH8 axis
Shuning Hao,
Feifei Zuo,
Hongmin Zhang
et al.
Abstract:Long noncoding RNAs (LncRNAs) play essential roles in regulating gene expression in various biological processes. However, the function of lncRNAs in vascular smooth muscle cell (VSMC) transformation remains to be explained. In this work, we discover that a new bone marrow protein (BMP) signaling target, lncRNA RP11‐301G19.1, is significantly induced in BMP7‐treated VSMCs through lncRNA microarray analysis. Addition of BMP signaling inhibitor LDN‐193189 attenuates the expression of ACTA2 and SM‐22α, as well as… Show more
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