<scp>LncRNA MIR17HG</scp> promotes the proliferation, migration, and invasion of retinoblastoma cells by up‐regulating <scp>HIF</scp>‐1α expression via sponging <scp>miR</scp>‐155‐5p

Jiang, Yan; Deng, Yixuan; Cai, Yulian; Cong, Wendong

doi:10.1002/kjm2.12523

Cited by 8 publications

(7 citation statements)

References 36 publications

(65 reference statements)

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“…Furthermore, MIR17HG enhanced the gene and protein expression of HIF-1α in RB cells. Taken together, this study suggested the oncogenic effects of MIR17HG in RB mediated through the miR-155-5p/HIF-1α axis (Yan et al, 2022).…”

Section: Long Non-coding Rnas and Retinoblastomasupporting

confidence: 56%

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Role of non-coding RNAs and exosomal non-coding RNAs in retinoblastoma progression

Davoodi

Najafi

Ghale-Noie

et al. 2022

Front. Cell Dev. Biol.

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Retinoblastoma (RB) is a rare aggressive intraocular malignancy of childhood that has the potential to affect vision, and can even be fatal in some children. While the tumor can be controlled efficiently at early stages, metastatic tumors lead to high mortality. Non-coding RNAs (ncRNAs) are implicated in a number of physiological cellular process, including differentiation, proliferation, migration, and invasion, The deregulation of ncRNAs is correlated with several diseases, particularly cancer. ncRNAs are categorized into two main groups based on their length, i.e. short and long ncRNAs. Moreover, ncRNA deregulation has been demonstrated to play a role in the pathogenesis and development of RB. Several ncRNAs, such as miR-491-3p, miR-613,and SUSD2 have been found to act as tumor suppressor genes in RB, but other ncRNAs, such as circ-E2F3, NEAT1, and TUG1 act as tumor promoter genes. Understanding the regulatory mechanisms of ncRNAs can provide new opportunities for RB therapy. In the present review, we discuss the functional roles of the most important ncRNAs in RB, their interaction with the genes responsible for RB initiation and progression, and possible future clinical applications as diagnostic and prognostic tools or as therapeutic targets.

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Section: Long Non-coding Rnas and Retinoblastomasupporting

confidence: 56%

“…Yan et al (Yan et al, 2022) investigated the role of the lncRNA MIR17HG (miR-17-92a-1 cluster host gene) and its interaction with miR-155-5p and HIF-1α pathway in RB development. qRT-PCR showed that up-regulation of MIR17HG was negatively associated with miR-155-5p expression.…”

Section: Long Non-coding Rnas and Retinoblastomamentioning

confidence: 99%

Role of non-coding RNAs and exosomal non-coding RNAs in retinoblastoma progression

Davoodi

Najafi

Ghale-Noie

et al. 2022

Front. Cell Dev. Biol.

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“…In addition, MIR17HG has been shown to promote CRC progression through miR-17-5p [24]. Further adding to its importance, MIR17HG can also promote the proliferation, migration, and invasion of retinoblastoma cells through up-regulating HIF-1α expression by sponging miR-155-5p [25]. To the best of our knowledge, our study is the frst of its kind to demonstrate a considerable increase in serum MIR17HG levels in MM patients.…”

Section: Discussionmentioning

confidence: 55%

The Expression of Serum lncRNA MIR17HG in Patients with Multiple Myeloma and Its Clinical Significance

Feng

et al. 2023

European Journal of Cancer Care

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Objective. Multiple myeloma (MM) represents a malignant tumor with abnormal proliferation of plasma cells. The current study sought to investigate the changes in serum lncRNA MIR17HG (long noncoding RNA miR-17-92a-1 cluster host gene) levels in MM patients and its values in assessing the accuracy of MM diagnosis and predicting diagnosis. Methods. First, 108MM patients and 85 healthy controls were enrolled as the study subjects. The serum levels of MIR17HG in all subjects were determined by RT-qPCR. MM patients were clinically staged according to the Durie-Salmon (DS) and international staging system (ISS), and the levels of serum MIR17HG were compared among patients at different stages. The correlation of serum MIR17H level with serum creatinine (Scr), lactate dehydrogenase (LDH), and albumin (ALB) was analyzed using the Pearson method. The accuracy of the serum MIR17HG level in identifying MM was evaluated using receiver operating characteristic curves. The progression-free survival (PFS) and overall survival (OS) curves of MM patients were plotted using the Kaplan–Meier method. Results. Serum MIR17HG levels were up-regulated in MM patients and elevated with the development of DS and ISS stages. The serum MIR17HG was positively correlated with Scr and LDH and negatively correlated with ALB in MM patients. Serum MIR17HG level >1.485 could evaluate the accuracy of identifying MM. The PFS and OS were significantly shortened in MM patients with elevated MIR17HG levels. Conclusion. Our findings collectively indicate that the serum MIR17HG can aid the evaluation of accurate MM identification, and a high serum MIR17HG level can predict poor prognosis of patients with MM.

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“…MIR17HG was found to promote proliferation, migration, and invasion of RB cells in previous studies 28 . Among cell lines derived from the human retina, the established ARPE‐19 cell line has similar properties to the endogenous retinal pigment epithelium (RPE) and has therefore been used as a model for analyzing RPE expression profiles 29–35 .…”

Section: Discussionmentioning

confidence: 97%

Bioinformatics analysis proposes a possible role for long noncoding RNA MIR17HG in retinoblastoma

Wang,

Liang,

et al. 2024

Cancer Reports

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BackgroundRetinoblastoma (RB) is the most common prevalent intraocular malignancy among infants and children, particularly in underdeveloped countries. With advancements in genomics and transcriptomics, noncoding RNAs have been increasingly utilized to investigate the molecular pathology of diverse diseases.AimsThis study aims to establish the competing endogenous RNAs network associated with RB, analyse the function of mRNAs and lncRNAs, and finds the relevant regulatory network.Methods and ResultsThis study establishes a network of competing endogenous RNAs by Spearman correlation analysis and prediction based on RB patients and healthy children. Enrichment analyzes based on Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes are conducted to analyze the potential biological functions of lncRNA and mRNA networks. Weighted gene co‐expression network analysis (WGCNA) is employed to identify gene cluster modules exhibiting the strongest correlation with RB. The results indicate a significant correlation between the lncRNA MIR17HG (R = .73, p = .02) and the RB phenotype. ceRNA networks reveal downstream miRNAs (hsa‐mir‐425‐5p and hsa‐mir455‐5p) and mRNAs (MDM2, IPO11, and ITGA1) associated with MIR17Hg. As an inhibitor of the p53 signaling pathway, MDM2 can suppress the development of RB.ConclusionIn conclusion, lncRNAs play a role in RB, and the MIR17HG/hsa‐mir‐425‐5p/MDM2 pathway may contribute to RB development by inhibiting the p53 signaling pathway.

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LncRNA MIR17HG promotes the proliferation, migration, and invasion of retinoblastoma cells by up‐regulating HIF‐1α expression via sponging miR‐155‐5p

Cited by 8 publications

References 36 publications

Role of non-coding RNAs and exosomal non-coding RNAs in retinoblastoma progression

Role of non-coding RNAs and exosomal non-coding RNAs in retinoblastoma progression

The Expression of Serum lncRNA MIR17HG in Patients with Multiple Myeloma and Its Clinical Significance

Bioinformatics analysis proposes a possible role for long noncoding RNA MIR17HG in retinoblastoma

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