JMJD3 activation contributes to renal protection and regeneration following acute kidney injury in mice
Chao Yu,
Jinhua Tang,
Jianjun Yu
et al.
Abstract:We have recently demonstrated that Jumonji domain‐containing protein D3 (JMJD3), a histone demethylase of histone H3 on lysine 27 (H3K27me3), is protective against renal fibrosis, but its role in acute kidney injury (AKI) remains unexplored. Here, we report that JMJD3 activity is required for renal protection and regeneration in murine models of AKI induced by ischemia/reperfusion (I/R) and folic acid (FA). Injury to the kidney upregulated JMJD3 expression and induced expression of H3K27me3, which was coincide… Show more
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