2015
DOI: 10.1111/cup.12553
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JAK2‐positive cutaneous myelofibrosis presenting as sclerosing extramedullary hematopoietic tumors on the scalp: case presentation and review of the literature

Abstract: We report the second case of cutaneous myelofibrosis with a documented JAK2 activating mutation involving the scalp of a 67-year-old woman with primary myelofibrosis in her marrow. In contrast to the previous case, the biopsy revealed extensive lesional collagen deposition and closely mimicked a fibrohistiocytic proliferation. Similar rare lesions occurring in the setting of myeloproliferative neoplasms have been called sclerosing extramedullary hematopoietic tumors. These entities appear histomorphologically … Show more

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Cited by 12 publications
(23 citation statements)
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“…Women were more represented with the 53.7% (66/123) of cases, compared to the 46.3% (57/123) of men . Median age of AN at onset was 59 (IQR: 47–68).…”
Section: Resultsmentioning
confidence: 99%
See 3 more Smart Citations
“…Women were more represented with the 53.7% (66/123) of cases, compared to the 46.3% (57/123) of men . Median age of AN at onset was 59 (IQR: 47–68).…”
Section: Resultsmentioning
confidence: 99%
“…Regarding the primary site of malignancy, gastrointestinal (GI) tract accounted for 24.4% (30/123), breast for 17.9% (22/123) of cases, kidney for 8.1% (10/123), lung for 7.3% (9/123), thyroid for 7.3% (9/123), uterus for 6.5% (8/123), central nervous system (CNS) for 6.5% (8/123), liver for 3.3% (4/123) and other anatomic areas for 18.7% (23/123) of cases …”
Section: Resultsmentioning
confidence: 99%
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“…It is believed that sclerosis within the tumor was produced by fibroblasts, induced by cytokines released from clonal megakaryocytes. The presence of the JAK2 V617F mutation may also suggest the clonal nature of the lesion [ 4 ].…”
Section: To the Editormentioning
confidence: 99%