<scp>J</scp>apanese pediatric guideline for the treatment and management of bronchial asthma 2012

Hamasaki, Yuhei; Kohno, Yoichi; Ebisawa, Motohiro; Kondo, Naomi; Nishima, Sankei; Nishimuta, Toshiyuki; Morikawa, Akihiro; Aihara, Yukoh; Akasawa, Akira; Adachi, Yuichi; Arakawa, Hirokazu; Ikebe, Toshiichi; Ichikawa, Kunio; Inoue, Takuya; Iwata, Tadahisa; Urisu, Atsuo; Ohya, Yukihiro; Okada, Kenji; Odajima, Hiroshi; Katsunuma, Toshio; Kameda, Makoto; Kurihara, Kazuyuki; Sakamoto, Tatsuo; Shimojo, Naoki; Suehiro, Yutaka; Tokuyama, Kenichi; Nambu, Mitsuhiko; Fujisawa, Takao; Matsui, Toshimitsu; Matsubara, Tomoyo; Mayumi, Mitsufumi; Mochizuki, Hiroyuki; Yamaguchi, Koichi; Yoshihara, Shigemi

doi:10.1111/ped.12389

Cited by 21 publications

(30 citation statements)

References 31 publications

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“…Signatures designating informed consent were obtained. Exclusion criteria were as follows: severe atopic dermatitis and uncontrolled asthma (baseline FEV 1 < 80 % of predictive value) according to Japanese pediatric guideline for the treatment and management of bronchial asthma [18]. …”

Section: Methodsmentioning

confidence: 99%

Two-weeks-sustained unresponsiveness by oral immunotherapy using microwave heated cow’s milk for children with cow’s milk allergy

Takahashi

Taniuchi

Soejima

et al. 2016

Allergy Asthma Clin Immunol

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BackgroundSeveral studies have reported that oral immunotherapy (OIT) is effective for children with cow’s milk (CM) allergy. These studies reported the efficacy of OIT in terms of desensitization, but did not describe sustained unresponsiveness to CM. The aim of this study was to evaluate the efficacy of the OIT protocol using microwave heated cow’s milk (MH-CM) in terms of 2-weeks-sustained unresponsiveness (2-weeks-SU) and safety.MethodsForty-eight children were enrolled in this study. Thirty-one children agreed to receive rush OIT using MH-CM (the OIT group) and another 17 children who did not want to receive rush OIT formed the untreated group. Rates of desensitization and 2-weeks-sustained unresponsiveness were compared between the two groups at 1 year after the start of OIT. We followed up these rates and safety data for another year and for longer in the OIT group.ResultsNo children in the untreated group did not pass an open food challenge to CM. Of the 31 children in the OIT group, 14 (P = 0.002) achieved desensitization, and 8 (P = 0.036) achieved 2-weeks-SU to CM at 1 year from the start of OIT. Two years after the start of OIT, both the rate of desensitization and the rate of 2-weeks-SU in the OIT group significantly increased compared with the rates at 1 year (P = 0.025 and P = 0.008 respectively).ConclusionsThe rush OIT protocol using MH-CM was effective at inducing 2-weeks-SU s to CM and had a good safety profile in children with CM allergy.Trial registration Approval number: 324, Registered 3 February 2009

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Section: Methodsmentioning

confidence: 99%

Two-weeks-sustained unresponsiveness by oral immunotherapy using microwave heated cow’s milk for children with cow’s milk allergy

Takahashi

Taniuchi

Soejima

et al. 2016

Allergy Asthma Clin Immunol

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“…The prevalence of pediatric asthma in Japan was reported to be 4-18% in 2012 and has been increasing each year (1). Despite this, widespread acceptance of the asthma management guidelines and the accompanying increased use of LTRAs and inhaled steroids has reduced hospitalization of children with asthma and improved control of the condition.…”

Section: Discussionmentioning

confidence: 99%

“…LTRAs are used as basal or add-on drugs for long-term management of asthma in children (1). In addition, LTRAs are recommended as first-line treatment for AR with nasal obstruction as the primary complaint (5).…”

Section: Discussionmentioning

confidence: 99%

“…Patients were required to meet the following criteria: i) Aged from 2-14 years; ii) diagnosed with cedar pollen allergy within 2 years prior to enrolment based on detection of eosinophils in nasal discharge or Radio-Allergo-Sorbent Test data; iii) written consent to participate in the present study was provided by the parents; iv) outpatients; and v) the child's asthma was under reasonable control. Asthma symptoms were assessed according to the Japanese Guideline for Childhood Asthma 2012 (1).…”

Section: Methodsmentioning

confidence: 99%

“…The number of pediatric patients with asthma continues to increase each year in Japan (1). Control of asthma in children has improved with the widespread use of inhaled steroids and leukotriene receptor antagonists (LTRAs) to suppress inflammation; however, the response to these medications is not always satisfactory.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of a leukotriene receptor antagonist for pediatric cedar pollen allergy complicated by asthma

Yoshihara

Kikuchi

Saitou

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Leukotriene receptor antagonists (LTRAs) are identified as a monotherapy for asthma and allergic rhinitis; however, their use in children for treatment of these diseases has not been examined. Accordingly, the present study investigated the efficacy of pranlukast dry syrup for children with both pollinosis and asthma. The subjects were children receiving treatment for asthma who were also diagnosed with cedar pollen allergy. Patients were divided into a group that received continuous treatment with pranlukast (group A; n=20) and a group that commenced add-on treatment for pollinosis following the onset of symptoms (group B; n=20). Patients in group B were randomly allocated to subgroup B1 (add-on treatment with pranlukast dry syrup) or subgroup B2 (add-on treatment with a second-generation antihistamine). In both groups, nasal and ocular symptoms were evaluated every day and recorded in a diary. Exacerbation of nasal obstruction was demonstrated in group B; however, not in group A. There was a significant difference in symptoms observed between the two groups during the late peak pollen period (P<0.05). The incidence of nasal obstruction (defined as a nasal obstruction score ≥3 or use of a nasal steroid spray) was significantly lower in group A compared with group B (P<0.05). The maximum scores for sneezing and nasal obstruction during the late peak of the pollen season were lowest in group A, followed by subgroup B1 and subgroup B2. The present study demonstrated that long-term administration of LTRA for the management of asthma may improve nasal symptoms of pollinosis during the pollen season in children with pollinosis and asthma.

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Sex Differences in the Prevalence and Severity of Exercise‐Induced Bronchoconstriction in Kindergarteners in Japan

Shinohara

Ogawa

Nakaya

et al. 2019

J of Gen and Family Med

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Background Exercise‐induced bronchoconstriction (EIB), a strong positive predictor of asthma, becomes progressively less frequent with age. Although asthma tends to become less common only in boys during adolescence, sex differences in EIB, especially in preschoolers, remain unclear. To find EIB for early diagnosis and intervention asthma, mass‐screening tests considering sex differences in preschoolers are needed. In this study, we investigated whether sex differences influence the prevalence and severity of EIB in prepubertal children aged 5–6 years. Methods Fifty‐one children aged 5–6 years who were attending a kindergarten in Matsuyama City, Ehime, Japan, were enrolled in this cross‐sectional study. The children underwent a 6‐minute free‐running test in 2015. The peak expiratory flow rate (PEFR) was measured before exercise and 0, 3, 10, and 20 minutes after exercise. The severity of EIB was classified according to the reduction in PEFR, measured as the difference between the postexercise PEFR and the highest pre‐exercise PEFR. Results Of the 51 children (23 boys and 28 girls) enrolled, the prevalence of EIB defined as three criteria: a ≥15%, ≥20%, or ≥25% decrease was 54.9% (28/51), 41.2% (21/51), and 25.5% (13/51), respectively. The prevalence of EIB defined as ≥25% decrease was significantly higher in girls than in boys (39.3% vs 8.7%, P = .013). In girls, the mean percentage change in PEFR was significantly higher 20 minutes than 10 minutes postexercise (P = .043). Conclusions Sex difference in the prevalence and severity of EIB should be considered when evaluating EIB, even in young, prepubertal children.

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Japanese pediatric guideline for the treatment and management of bronchial asthma 2012

Cited by 21 publications

References 31 publications

Two-weeks-sustained unresponsiveness by oral immunotherapy using microwave heated cow’s milk for children with cow’s milk allergy

Two-weeks-sustained unresponsiveness by oral immunotherapy using microwave heated cow’s milk for children with cow’s milk allergy

Efficacy of a leukotriene receptor antagonist for pediatric cedar pollen allergy complicated by asthma

Sex Differences in the Prevalence and Severity of Exercise‐Induced Bronchoconstriction in Kindergarteners in Japan

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