INPP5E Regulates the Distribution of Phospholipids on Cilia in RPE1 Cells
Denghui Zhai,
Lamei Li,
Cheng Chen
et al.
Abstract:BackgroundPrimary cilia are static microtubule‐based structures protruding from the cell surface and present on most vertebrate cells. The appropriate localization of phospholipids is essential for cilia formation and stability. INPP5E is a cilia‐localized inositol 5‐phosphatase; its deletion alters the phosphoinositide composition in the ciliary membrane, disrupting ciliary function.MethodsThe EGFP‐2xP4MSidM, PHPLCδ1‐EGFP, and SMO‐tRFP plasmids were constructed by the Gateway system to establish a stable RPE1… Show more
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