<scp><i>HIF1A</i></scp> as a major vascular endothelial growth factor regulator: do its polymorphisms have an association with age‐related macular degeneration?

Okur, Volkan; Cetin, Ozan; Çetin, Ebru; Tepeli, Emre; Bulgu, Yunus; Yıldırım, Cem

doi:10.1111/ceo.12376

Cited by 8 publications

(6 citation statements)

References 29 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, Okur et al . did confirm a statistically significant association of a specific SNP of the CFH gene, rs1061170, and AMD in the studied population …”

supporting

confidence: 58%

See 1 more Smart Citation

Hypoxia inducible factor single nucleotide polymorphisms: exploring the role of HIF polymorphisms in retinal disease

Kittipassorn

Peet

2015

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

“…Interestingly, Okur et al . did confirm a statistically significant association of a specific SNP of the CFH gene, rs1061170, and AMD in the studied population …”

supporting

confidence: 58%

“…In this issue, Okur et al . report on the investigation into the association of polymorphisms of HIF1A (encoding the HIF‐1α protein), and other related genes, with AMD …”

mentioning

confidence: 99%

Hypoxia inducible factor single nucleotide polymorphisms: exploring the role of HIF polymorphisms in retinal disease

Kittipassorn

Peet

2015

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

“…Furthermore, resveratrol regulates gene expression to exert its biological function, while the understanding of its regulatory mechanism is not sufficiently known. Importantly, resveratrol has been reported to be a potential epigenetic factor [24], and the current investigations indicated the regulatory role of resveratrol in DNA methylation [25] and histone modification [26], suggesting that resveratrol also probably exerts its hepatic protection function through regulating the modification of m 6 A.…”

Section: Introductionmentioning

confidence: 65%

Resveratrol Attenuates Aflatoxin B1-Induced ROS Formation and Increase of m6A RNA Methylation

Gan

Zhuo

et al. 2020

Animals

View full text Add to dashboard Cite

Aflatoxin B1 (AFB1) is one of the most dangerous mycotoxins in both humans and animals. Regulation of resveratrol is essential for the inhibition of AFB1-induced oxidative stress and liver injury. Whether N6-methyladenosine (m6A) mRNA methylation participates in the crosstalk between resveratrol and AFB1 is unclear. The objective of this study was to investigate the effects of AFB1 and resveratrol in m6A RNA methylation and their crosstalk in the regulation of hepatic function in mice. Thirty-two C57BL/6J male mice were randomly assigned to a CON (basal diet), RES (basal diet + 500 mg/kg resveratrol), AFB1 (basal diet + 600 μg/kg aflatoxin B1), and ARE (basal diet + 500 mg/kg resveratrol and 600 μg/kg aflatoxin B1) group for 4 weeks of feeding (n = 8/group). Briefly, redox status, apoptosis, and m6A modification in the liver were assessed. Compared to the CON group, the AFB1 group showed increased activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), prevalent vacuolization and cell edema, abnormal redox status, imbalance apoptosis, and especially, the higher expression of cleaved-caspase-3 protein. On the contrary, resveratrol ameliorated adverse hepatic function, via increasing hepatic antioxidative capacity and inhibiting the expression of cleaved-caspase-3 protein. Importantly, we noted that reactive oxygen species (ROS) content could be responsible for the alterations of m6A modification. Compared to the CON group, the AFB1 group elevated the ROS accumulation, which led to the augment in m6A modification, whereas dietary resveratrol supplementation decreased ROS, followed by the reduction of m6A levels. In conclusion, our findings indicated that resveratrol decreased AFB1-induced ROS accumulation, consequently contributing to the alterations of m6A modification, and eventually impacting on the hepatic function.

show abstract

“…Also, Lin et al [ 33 ] reported that the HIF1A 1790 G/A might be played a protecting role significantly to develop the lumbar disc degeneration (LDD), and HIF1A 1772 C/T did not play any role with the severity of LDD. Some authors also checked the association of the HIF1A gene with cellulite [ 28 ], hemodialysis patients [ 30 ], high-altitude polycythemia (HAPC) [ 36 ], and age-related macular degeneration (AMD) [ 23 ]. They found the significant association of HIF1A with cellulite, and insignificant association of HIF1A with hemodialysis patients, HAPC and AMD risk.…”

Section: Introductionmentioning

confidence: 99%

Association of hypoxia inducible factor 1-Alpha gene polymorphisms with multiple disease risks: A comprehensive meta-analysis

et al. 2022

View full text Add to dashboard Cite

HIF1A gene polymorphisms have been confirmed the association with cancer risk through the statistical meta-analysis based on single genetic association (SGA) studies. A good number SGA studies also investigated the association of HIF1A gene with several other diseases, but no researcher yet performed statistical meta-analysis to confirm this association more accurately. Therefore, in this paper, we performed a statistical meta-analysis to draw a consensus decision about the association of HIF1A gene polymorphisms with several diseases except cancers giving the weight on large sample size. This meta-analysis was performed based on 41 SGA study’s findings, where the polymorphisms rs11549465 (1772 C/T) and rs11549467 (1790 G/A) of HIF1A gene were analyzed based on 11544 and 7426 cases and 11494 and 7063 control samples, respectively. Our results showed that the 1772 C/T polymorphism is not significantly associated with overall disease risks. The 1790 G/A polymorphism was significantly associated with overall diseases under recessive model (AA vs. AG + GG), which indicates that the A allele is responsible for overall diseases though it is recessive. The subgroup analysis based on ethnicity showed the significant association of 1772 C/T polymorphism with overall disease for Caucasian population under the all genetic models, which indicates that the C allele controls overall diseases. The ethnicity subgroup showed the significant association of 1790 G/A polymorphism with overall disease for Asian population under the recessive model (AA vs. AG + GG), which indicates that the A allele is responsible for overall diseases. The subgroup analysis based on disease types showed that 1772 C/T is significantly associated with chronic obstructive pulmonary disease (COPD) under two genetic models (C vs. T and CC vs. CT + TT), skin disease under two genetic models (CC vs. TT and CC + CT vs. TT), and diabetic complications under three genetic models (C vs. T, CT vs. TT and CC + CT vs. TT), where C allele is high risk factor for skin disease and diabetic complications (since, ORs > 1), but low risk factor for COPD (since, ORs < 1). Also the 1790 G/A variant significantly associated with the subgroup of cardiovascular disease (CVD) under homozygote model, diabetic complications under allelic and homozygote models, and other disease under four genetic models, where the A is high risk factor for diabetic complications and low risk factor for CVD. Thus, this study provided more evidence that the HIF1A gene is significantly associated with COPD, CVD, skin disease and diabetic complications. These might be the severe comorbidities and risk factors for multiple cancers due to the effect of HIF1A gene and need further investigations accumulating large number of studies.

show abstract

HIF1A as a major vascular endothelial growth factor regulator: do its polymorphisms have an association with age‐related macular degeneration?

Abstract: No associations appeared between HIF1A SNPs and AMD, which were studied here for the first time; however, polymorphism rs1061170 of the CFH gene is associated with AMD in our population.

Cited by 8 publications

References 29 publications

Hypoxia inducible factor single nucleotide polymorphisms: exploring the role of HIF polymorphisms in retinal disease

Hypoxia inducible factor single nucleotide polymorphisms: exploring the role of HIF polymorphisms in retinal disease

Resveratrol Attenuates Aflatoxin B1-Induced ROS Formation and Increase of m6A RNA Methylation

Association of hypoxia inducible factor 1-Alpha gene polymorphisms with multiple disease risks: A comprehensive meta-analysis

Contact Info

Product

Resources

About