FMR1 Carriers Report Executive Function Changes Prior to Fragile X‐Associated Tremor/Ataxia Syndrome: A Longitudinal Study
David Hessl,
Karina Mandujano Rojas,
Emilio Ferrer
et al.
Abstract:BackgroundMen with fragile X‐associated tremor/ataxia syndrome (FXTAS) often develop executive dysfunction, characterized by disinhibition, frontal dyscontrol of movement, and working memory and attention changes. Although cross‐sectional studies have suggested that earlier executive function changes may precede FXTAS, the lack of longitudinal studies has made it difficult to address this hypothesis.ObjectiveTo determine whether executive function deterioration experienced by premutation carriers (PC) in daily… Show more
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