<scp>CDK5R1</scp>, <scp>GSE1</scp>, <scp>HSPG2</scp> and <scp>WDFY3</scp> as indirect epigenetic‐sensitive genes in atrial fibrillation

Infante, Teresa; Pepin, Mark E.; Ruocco, Antonio; Trama, Ugo; Mauro, Ciro; Napoli, Claudio

doi:10.1111/eci.14135

Cited by 3 publications

(1 citation statement)

References 71 publications

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“…DNA methylation at the candidate gene locus has been linked to the progression of hypertension 38 and hypertrophy, 39 supporting differences we observed in the hyper and hypomethylated DMR genes. In the context of the angiogenesis and CV-TOI, among the DMR genes, key genes are GSE1, for which differential methylation has been previously reported in patients with left ventricular hypertrophy and atrial fibrillation, 40,41 and VAV2, a guanine nucleotide exchange factor for Ras-related GTPases and modulate receptor-mediated angiogenic responses. Though there is no evidence for VAV2 methylation in blood pressure or cardiac diseases, it has been significantly associated with left ventricular hypertrophy, cardiac fibrosis, and hypertension.…”

Section: Whole Genome Methylation In Pathogenesis Of Hypertension-ind...mentioning

confidence: 99%

A Multi-Omics Approach to Defining Target Organ Injury in Youth with Primary Hypertension

Ananthamohan,

Brady,

Arif

et al. 2024

Preprint

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BACKGROUNDPrimary hypertension in childhood tracks into adulthood and may be associated with increased cardiovascular risk. Studies conducted in children and adolescents provide an opportunity to explore the early cardiovascular target organ injury (CV-TOI) in a population free from many of the co-morbid cardiovascular disease risk factors that confound studies in adults.METHODSYouths (n=132, mean age 15.8 years) were stratified by blood pressure (BP) as low, elevated, and high-BP and by left ventricular mass index (LVMI) as low- and high-LVMI. Systemic circulating RNA, miRNA, and methylation profiles in peripheral blood mononuclear cells and deep proteome profiles in serum were determined using high-throughput sequencing techniques.RESULTSVASH1gene expression was elevated in youths with high-BP with and without high-LVMI.VASH1expression levels positively correlated with systolic BP (r=0.3143, p=0.0034). The expression of hsa-miR-335-5p, one of theVASH1-predicted miRNAs, was downregulated in high-BP with high-LVMI youths and was inversely correlated with systolic BP (r=-0.1891, p=0.0489).GSE1hypermethylation, circulating PROZ upregulation (log2FC=0.61, p=0.0049 and log2FC=0.62, p=0.0064), and SOD3 downregulation (log2FC=-0.70, p=0.0042 and log2FC=-0.64, p=0.010) were observed in youths with elevated BP and high-BP with high-LVMI. Comparing the transcriptomic and proteomic profiles revealed elevatedHYAL1levels in youths displaying high-BP and high-LVMI.CONCLUSIONSThe findings are compatible with a novel blood pressure-associated mechanism that may occur through impaired angiogenesis and extracellular matrix degradation through dysregulation of Vasohibin-1 and Hyaluronidase1 was identified as a possible mediator of CV-TOI in youth with high-BP and suggests strategies for ameliorating TOI in adult-onset primary hypertension.

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Section: Whole Genome Methylation In Pathogenesis Of Hypertension-ind...mentioning

confidence: 99%

A Multi-Omics Approach to Defining Target Organ Injury in Youth with Primary Hypertension

Ananthamohan,

Brady,

Arif

et al. 2024

Preprint

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Cellular and molecular biology of posttranslational modifications in cardiovascular disease

Zhu,

Liu,

Huang

et al. 2024

Biomedicine & Pharmacotherapy

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The Identification of Key Genes and Biological Pathways in Cardiac Arrest by Integrated Bioinformatics and Next Generation Sequencing Data Analysis

Vastrad,

Vastrad

2024

Preprint

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Cardiac arrest (CA) is a common cause of death world wide. The disease has lacks effective treatment. Efforts have been made to elucidate the molecular pathogenesis of CA, but the molecular mechanisms remain elusive. To identify key genes and pathways in CA, the next generation sequencing (NGS) GSE200117 dataset was downloaded from the Gene Expression Omnibus (GEO) database. DESeq2 tool was used to recognize differentially expressed genes (DEGs). Gene ontology (GO) and REACTOME pathway enrichment analyses were performed to analyze the DEGs and associated signal pathways in the g:Profiler database. The IID database was used to construct the protein-protein interaction (PPI) network, and modules analysis was performed using Cytoscape. A miRNA-hub gene regulatory network and TF-hub gene regulatory network were then constructed to screen miRNAs, TFs and hub genes by miRNet and NetworkAnalyst database and Cityscape software. Receiver operating characteristic curve (ROC) analysis used to verified the hub genes. In total, 844 DEGs were identified, comprising 414 up regulated genes and 430 down regulated genes. GO and REACTOME pathway enrichment analyses indicated that the DEGs for CA were mainly enriched in organonitrogen compound metabolic process, response to stimulus, translation and immune system. Ten hub genes (up-regulated: HSPA8, HOXA1, INCA1 and TP53; down-regulated: HSPB1, LMNA, SNCA, ADAMTSL4 and PDLIM7) were screened. We also predicted miRNAs (hsa-mir-1914-5p and hsa-mir-598-3p) and TFs (JUN and PRRX2) targeting hub genes. This study uses a series of bioinformatics technologies to obtain hug genes, miRNAs and TFs, and key pathways related to CA. These analysis results provide us with new ideas for finding biomarkers and treatment methods for CA.

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CDK5R1, GSE1, HSPG2 and WDFY3 as indirect epigenetic‐sensitive genes in atrial fibrillation

Cited by 3 publications

References 71 publications

A Multi-Omics Approach to Defining Target Organ Injury in Youth with Primary Hypertension

A Multi-Omics Approach to Defining Target Organ Injury in Youth with Primary Hypertension

Cellular and molecular biology of posttranslational modifications in cardiovascular disease

The Identification of Key Genes and Biological Pathways in Cardiac Arrest by Integrated Bioinformatics and Next Generation Sequencing Data Analysis

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