<scp>BRCA</scp>1 mutation site may be linked with nuclear <scp>DNA</scp> ploidy in <scp>BRCA</scp>1‐mutated ovarian carcinomas

Aghmesheh, Morteza; Saxena, Akshat; Niknam, Farshid

doi:10.1111/ajco.12310

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…Aneuploidy is a result of the chromosomal instability of cancer cells and is thought to contribute to the initiation and progression of most carcinomas [ 15 ]. Aghmesheh et al, 2015 [ 24 ] stated that higher risk for aneuploidy in ovarian tumours was associated with BRCA1 mutations near the N- terminal.…”

Section: Discussionmentioning

confidence: 99%

DNA Cytometry and Nuclear Morphometry in Ovarian Benign, Borderline and Malignant Tumors

Din

Badawi

Aal

et al. 2015

Open Access Maced J Med Sci

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BACKDROUND:Ovarian carcinoma is a leading cause of death in gynecological malignancy. Ovarian surface epithelial serous and mucinous tumours are classified as benign, borderline, and malignant. The identification of borderline tumours most likely to act aggressively remains an important clinical issue.AIM:This work aimed to study DNA ploidy and nuclear area in ovarian serous and mucinous; benign, borderline and malignant tumours.MATERIAL AND METHODS:This study included forty ovarian (23 serous and 17 mucinous) tumours. Paraffin blocks were sectioned; stained with haematoxylin and eosin for histopathologic and morphometric studies and with blue feulgen for DNA analysis.RESULTS:All four serous and six out of nine mucinous benign tumours were diploid. All eight serous and five mucinous malignant tumours were aneuploid. Nine of eleven (81.8%) serous and all three mucinous borderline tumours were aneuploid. There were highly significant differences in mean aneuploid cells percentage between serous benign (1.5%), borderline (45.6%) and malignant (74.5%) (p = 0.0001) and between mucinous benign (13.2%) and both borderline (63.7%) and malignant (68.4%) groups (p = 0.0001). There were significant differences in nuclear area between serous benign (26.191%), borderline (45.619%) and malignant (67.634 %) and a significant positive correlation between mean percentage aneuploid value and mean nuclear area in all serous and mucinous groups.CONCLUSION:We suggest that DNA ploidy and nuclear area combined, may be adjuncts to histopathology; in ovarian serous and mucinous benign, borderline and malignant neoplasms; identifying the aggressive borderline tumours.

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Section: Discussionmentioning

confidence: 99%