HTRA1 promotes EMT through the HDAC6/Ac‐α‐tubulin pathway in human GBM cells
Wenbo Zhao,
Yibo Wu,
Shuai Wang
et al.
Abstract:BackgroundThe infiltrative nature of human gliomas renders complete surgical removal of tumors futile. Thus, illuminating mechanisms of their infiltrative properties may improve therapies and outcomes of glioma patients.MethodsComprehensive bioinformatic analyses of PRSS family were undertaken. Transfection of HTRA1 siRNAs was used to suppress HTRA1 expression. CCK‐8, EdU, and colony formation assay were employed to assess cell viability, and cell migration/invasion was detected by transwell, wound healing, an… Show more
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